A genetic mutation reduces expression of a sodium-dependent glucose transporter on enterocytes. Which combination of immediate absorption change and downstream systemic effect is most likely?

• A. Reduced active glucose uptake from the lumen leading to decreased postprandial portal glucose delivery and potential hypoglycemia between meals if compensatory mechanisms fail.
• B. Increased passive diffusion of glucose across the lipid bilayer that fully compensates, so no change in systemic glucose levels would be observed.
• C. Enhanced fat absorption due to channel cross-activation, causing hyperlipidemia and no effect on glucose handling.
• D. Immediate diversion of all dietary glucose to lacteals and lymphatics resulting in elevated chylomicron-associated glucose concentrations in peripheral tissues.

Answer: (A)