If a new drug is highly lipophilic and small, what absorption modification would most increase its rate of passive uptake across enterocytes?

• A. Administering it with a competitive polar nutrient that uses the same channel, since channel competition enhances passive uptake across bilayers.
• B. Adding a large charged moiety to the molecule to increase its water solubility so it will dissolve in the lumen and be absorbed faster by passive diffusion.
• C. Co-administering it with a fatty meal to enhance its solubilization and partitioning into the lipid bilayer, increasing passive absorption.
• D. Blocking all lacteals so lipophilic molecules cannot enter lymph and therefore will be forced to diffuse directly into portal capillaries.

Answer: (C)