Nucleophilic Acyl Substitution

22. Carboxylic Acid Derivatives: NAS / Nucleophilic Acyl Substitution – The Three Rules / Problem 4

Problem 4

Suggest a mechanism for this nucleophilic acyl substitution.

Detailed mechanism of nucleophilic acyl substitution with electron flow arrows.

Alternative mechanism for nucleophilic acyl substitution with electron flow arrows.

Another mechanism for nucleophilic acyl substitution with electron flow arrows.

Final step of nucleophilic acyl substitution mechanism with electron flow arrows.