give-the-estimated-pka-value-of-the-indicated-proton-in-the-structure-of-3-methy

Question

Using your knowledge of important pK_a values, estimate the pK_a value of the indicated proton and explain your choice.

Chemical structure illustrating pKa values of hydroxyl, carboxylic acid, and α-carbon protons.

Accepted Answer

pK_a = 5; The indicated proton belongs to the carboxylic acid functional group.

Answer

pK_a = 16; The indicated proton is part of a hydroxyl group, so its pK_a is that of an alcohol.

Answer

pK_a = −2; The emphasized proton is part of O⁺—H.

Answer

pK_a = 20; The hydrogen emphasized is attached to an α-carbon.

Using your knowledge of important pKa values, estimate the pKa value of the indicated proton and explain your choice.