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Transesterification
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Transesterification
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22. Carboxylic Acid Derivatives: NAS / Transesterification / Problem 2
Problem 2
How are transesterification reactions catalyzed by tertiary amines?
A
The 3° amine stabilizes the tetrahedral intermediate, making the elimination of the alkoxide group of the starting ester more likely.
B
An acid-base reaction occurs between the 3° amine and alcohol, forming an alkoxide ion that is a stronger nucleophile.
C
The 3° amine forms a complex with the carbonyl group, making it more susceptible to a nucleophilic attack from an alcohol.
D
Nucleophilic attack by the 3° amine forms a positively-charged amide that is more reactive than the starting ester.
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