Question 1

Which of the following best describes the mechanism of nucleophilic condensation of aldehydes and ketones with ammonia and its derivatives?

Accepted Answer

Nucleophilic addition followed by elimination

Question 2

What is the product when cyclohexanone reacts with hydroxylamine ($$\mathrm{NH_2OH}) in a $$condensation reaction?

Accepted Answer

Cyclohexanone oxime

Question 3

Which reagent would you use to convert an aldehyde into a hydrazone?

Accepted Answer

Hydrazine ($$\mathrm{NH_2NH_2})$$

Question 4

Which of the following statements about keto-enol tautomerism is correct?

Accepted Answer

Keto and enol forms are structural isomers.

Question 5

Why is the $$\alpha-$$hydrogen in a carbonyl compound more acidic than a typical hydrogen bonded to carbon?

Accepted Answer

Because the carbonyl oxygen withdraws electron density, making the $$\alpha-$$hydrogen easier to remove.

Question 6

What is the name of the anion formed when a base removes an $$\alpha-$$hydrogen from a carbonyl compound?

Accepted Answer

Enolate anion

Question 7

In an aldol condensation, what is the initial product before dehydration occurs?

Accepted Answer

$$\beta-$$hydroxy carbonyl compound

Question 8

Which of the following is true about crossed aldol condensation?

Accepted Answer

It is a reaction between two different carbonyl compounds.

Question 9

Which of the following is a real-world application of formaldehyde in pharmacy?

Accepted Answer

Used as a preservative in vaccine formulations

Question 10

Benzaldehyde is commonly used as an artificial flavoring because it imparts which flavor?

Accepted Answer

Almond

Question 11

Which compound is responsible for the odor of ripe raspberries?

Accepted Answer

3-(4-hydroxyphenyl)butan-2-one

Question 12

Which of the following reactions would produce an oxime?

Accepted Answer

Ketone + hydroxylamine

Question 13

What is the role of the enolate ion in the aldol condensation reaction?

Accepted Answer

It acts as a nucleophile attacking another carbonyl group.

Question 14

Which of the following is a correct description of condensation reactions with amines?

Accepted Answer

Primary amines react with carbonyl compounds to form imines.

Question 15

Which of the following is a product of the reaction between an aldehyde and semicarbazide?

Accepted Answer

Semicarbazone

Question 16

Which of the following naturally occurring carbonyl compounds is found in lemon grass oil?

Accepted Answer

Citral

Question 17

Which of the following statements about the importance of carbonyl compounds in pharmacy is correct?

Accepted Answer

Aldehydes and ketones are used as building blocks in the synthesis of pharmaceuticals and polymers.

Question 18

Which of the following steroids contains a carbonyl group in its structure?

Accepted Answer

Testosterone

Question 19

A student mixes acetaldehyde and acetone in the presence of base. Which type of reaction is most likely to occur?

Accepted Answer

Crossed aldol condensation

Question 20

Which of the following is a correct statement about the dehydration step in aldol condensation?

Accepted Answer

It converts a $$\beta-$$hydroxy carbonyl compound into an $$\alpha,\beta-$$unsaturated carbonyl compound.

Aldehydes and Ketones-II: Condensation Reactions, Aldol Chemistry, and Pharmaceutical Importance

Study Guide - Practice Questions