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Organic Chemistry II (CHE251) Final Exam Review Topics – Structured Study Notes

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Intro to Organic Chemistry

Hybridization

Molecular Geometry

Formal Charges

Resonance Structures

Acids and Bases

pKa

Ranking Acidity

Reaction Mechanism

Nucleophilic Substitution

SN2 Reaction

SN1 Reaction

Carbocation Stability

Carbocation Intermediate Rearrangements

E2 Mechanism

E1 Reaction

Solvents

Leaving Groups

Nucleophiles and Basicity

SN1 SN2 E1 E2 Chart (Big Daddy Flowchart)

Alkene Stability

Zaitsev Rule

Dehydrohalogenation

Alcohol Nomenclature

Oxidizing and Reducing Agents

Alkane Halogenation

Radical Reaction

Radical Stability

Free Radical Halogenation

Radical Selectivity

Allylic Bromination

Anti Markovnikov Addition of Br

Conjugation Chemistry

Stability of Conjugated Intermediates

Diels-Alder Reaction

Electrophilic Aromatic Substitution

Benzene Reactions

EAS:Halogenation Mechanism

EAS:Nitration Mechanism

EAS:Friedel-Crafts Alkylation Mechanism

EAS:Friedel-Crafts Acylation Mechanism

EAS:Any Carbocation Mechanism

Electron Withdrawing Groups

EAS:Ortho vs. Para Positions

Limitations of Friedel-Crafts Alkyation

Advantages of Friedel-Crafts Acylation

Side-Chain Halogenation

Side-Chain Oxidation

Reactions at Benzylic Positions

Nucleophilic Aromatic Substitution

Oxidation of Phenols to Quinones

Cleavage of Phenyl Ethers

Reactions of Pyrrole, Furan, and Thiophene

Directing Effects in Substituted Pyrroles, Furans, and Thiophenes

Addition Reactions of Furan

EAS Reactions of Pyridine

SNAr Reactions of Pyridine

Side-Chain Reactions of Substituted Pyridines