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Organic Chemistry in Drug Synthesis: Multi-Step Synthesis and Reaction Mechanisms

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Overview of Chemical Reactions

  • Recognizing Substitution Reactions.
    01:34
  • Recognizing Acid-Base Reactions.
    02:43
  • Recognizing Elimination Reactions.
    00:40

Reaction Mechanism

  • How to tell if charged molecules will react as nucleophiles or electrophiles.
    02:39
  • Nucleophile or Electrophile
    01:49
  • How to tell if uncharged molecules will react as nucleophiles or electrophiles.
    02:48

Alcohol Synthesis

  • Forming alcohols through SN2 reactions.
    01:44
  • Forming alcohols through Acid-Catalyzed Hydration.
    02:02
  • Forming alcohols through Hydroboration-Oxidation.
    01:37

Leaving Group Conversions - Using HX

  • Why do we need to convert Alcohol into a good leaving group?
    02:03
  • Using HX acids via SN2 reaction.
    02:16
  • Using HX acids via SN1 reaction.
    07:20

Leaving Group Conversions - SOCl2 and PBr3

  • Predict the mechanism of PBr3, and draw the final product.
    06:01
  • Learning the mechanism of SOCl2.
    07:18

Leaving Group Conversions - Sulfonyl Chlorides

  • Learning the mechanism of Sulfonyl Chlorides.
    05:33

Leaving Group Conversions Summary

  • Comparing and contrasting the Alcohol Conversions.
    04:30

Introduction to Substitution

  • Predict the product
    05:55
  • Nucleophiles and Electrophiles can react in Bronsted-Lowry Reactions.
    05:01
  • Nucleophiles and Electrophiles can react in Substitution Reactions.
    01:47

The SN2 Mechanism

  • Ranking reactivity toward SN2
    04:03
  • Drawing the SN2 Mechanism
    08:33
  • Understanding the properties of SN2.
    11:57

SN1 Reaction

  • Drawing the SN1 Mechanism
    10:49
  • Why highly substituted leaving groups favor SN1.
    01:13
  • Understanding the properties of SN1.
    08:16

Solvents

  • The difference between protic vs. aprotic solvents.
    03:57
  • Identification of polarity in solvents
    01:16
  • Identification of polarity in solvents
    00:39

Protecting Alcohols from Organometallics

  • Use of Protecting Groups
    04:34
  • Provide mechanism and final product of transformation.
    04:45

Alcohol Protecting Groups

  • General features of Alcohol Protecting Groups.
    03:01

Silyl Ether Protecting Groups

  • Mechanism of Silyl Ether Protecting Groups.
    07:16
  • Predict the product of the following reaction.
    03:37

Hydrogenation

  • General properties of catalytic hydrogenation.
    05:21

Nucleophilic Addition

  • Nucleophilic Addition
    08:27