Question 1

In the structure of acetylsalicylic acid (aspirin), what is the hybridization of the carbon atom in the carboxylic acid group that is double-bonded to oxygen?

Accepted Answer

$$sp^2$$

Question 2

Which of the following functional groups is present in both ibuprofen and naproxen?

Accepted Answer

Carboxylic acid

Question 3

In the molecule of capsaicin, which type of bond is formed between the nitrogen and the carbonyl carbon in the amide group?

Accepted Answer

One $$\sigma$$ and one $$\pi$$ bond

Question 4

Which atom in acetaminophen (Tylenol) is most likely to have a localized lone pair of electrons?

Accepted Answer

The nitrogen in the amide group

Question 5

In the structure of fexofenadine, which carbon is a quaternary carbon?

Accepted Answer

The carbon attached to three methyl groups (tert-butyl group)

Question 6

Which of the following bonds in naproxen is the most polar?

Accepted Answer

C–O (in the methoxy group)

Question 7

What is the geometry around the nitrogen atom in the amide group of acetaminophen?

Accepted Answer

Trigonal planar

Question 8

Which of the following statements about the aromatic rings in ibuprofen and naproxen is correct?

Accepted Answer

Each aromatic ring contains six $$\pi$$ electrons.

Question 9

Which of the following best describes the relationship between acetylsalicylic acid (aspirin) and acetaminophen (Tylenol)?

Accepted Answer

They have no relation.

Question 10

In the structure of capsaicin, which type of orbital overlap forms the C=O bond in the amide group?

Accepted Answer

$$sp^2$$–$$sp^2$$ for $$\sigma$$ and $$p$$–$$p$$ for $$\pi$$

Question 11

Which of the following molecules contains a delocalized electron system?

Accepted Answer

Ibuprofen

Question 12

What is the formal charge on the nitrogen atom in the amide group of acetaminophen?

Accepted Answer

$$0$$

Question 13

Which of the following best describes the condensed structural formula for the carboxylic acid group?

Accepted Answer

$$CH_3COOH$$

Question 14

In fexofenadine, which functional group is responsible for its acidic properties?

Accepted Answer

Carboxylic acid

Question 15

Which of the following statements about resonance structures is correct?

Accepted Answer

Resonance structures differ only in the arrangement of electrons.

Question 16

How many $$\pi$$ bonds are present in the aromatic ring of acetylsalicylic acid?

Accepted Answer

3

Question 17

Which of the following best describes the relationship between ibuprofen and naproxen?

Accepted Answer

They have no relation.

Question 18

In the structure of capsaicin, which carbon is a secondary carbon?

Accepted Answer

A carbon attached to two other carbons and two hydrogens

Question 19

Which of the following best describes the geometry around the oxygen atom in the hydroxyl group of acetaminophen?

Accepted Answer

Bent

Question 20

Which of the following is a correct expanded structural formula for the methyl group attached to the nitrogen in the first molecule shown?

Accepted Answer

$$CH_3$$

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