Question 1

Which of the following statements best describes the relationship between cis- and trans-1,2-dichloroethene?

Accepted Answer

They are diastereomers because they are stereoisomers that are not mirror images.

Question 2

A molecule with the formula $$CHXYZ ($$where X, Y, and Z are all different groups) is most likely to exhibit which property?

Accepted Answer

It will be chiral and have a non-superimposable mirror image.

Question 3

Which of the following is TRUE about enantiomers?

Accepted Answer

Enantiomers have identical physical properties except for their interaction with plane-polarized light.

Question 4

What is the key structural requirement for a carbon atom to be a stereocenter (chiral center)?

Accepted Answer

It must be attached to four different groups.

Question 5

Which property is NOT typically different between diastereomers?

Accepted Answer

Molecular formula

Question 6

Consider the following molecules: (2R,3R)-2,3-dibromobutane and (2S,3S)-2,3-dibromobutane. What is their stereochemical relationship?

Accepted Answer

They are enantiomers.

Question 7

Which of the following statements about plane-polarized light (PPL) is correct?

Accepted Answer

Chiral molecules rotate PPL, and the direction depends on the enantiomer.

Question 8

A solution of a chiral compound rotates plane-polarized light to the left. What term describes this rotation?

Accepted Answer

Levorotatory

Question 9

Which of the following is NOT a method for separating enantiomers?

Accepted Answer

Simple distillation

Question 10

Which of the following best describes a meso compound?

Accepted Answer

A compound with chiral centers that is achiral due to an internal plane of symmetry.

Question 11

What is the expected bond angle around a tetrahedral carbon atom?

Accepted Answer

$$109.5^\circ$$

Question 12

Which of the following is TRUE about cis-trans isomerism in cycloalkanes?

Accepted Answer

Cis-trans isomers in cycloalkanes are diastereomers.

Question 13

Which of the following molecules is chiral?

Accepted Answer

2-butanol

Question 14

If a compound has two stereocenters, how many possible stereoisomers can it have (assuming no meso forms)?

Accepted Answer

$$4$$

Question 15

Which of the following is a correct statement about diastereomers?

Accepted Answer

Diastereomers have different physical properties.

Question 16

Which of the following is the correct definition of a stereoisomer?

Accepted Answer

Compounds with the same molecular formula and connectivity but different arrangement in space.

Question 17

Which of the following is NOT a property that can be used to distinguish diastereomers?

Accepted Answer

Molecular weight

Question 18

A compound with two chiral centers can be meso if:

Accepted Answer

It has an internal plane of symmetry.

Question 19

Which of the following is TRUE about the mirror image of cis-1,2-dichloroethene?

Accepted Answer

It is superimposable on the original cis molecule.

Question 20

Which of the following is the correct relationship between (2R,3S)-2,3-dibromobutane and (2S,3R)-2,3-dibromobutane?

Accepted Answer

They are enantiomers.

Stereochemistry: Isomer Classification, Cis-Trans Isomerism, and Chirality

Study Guide - Practice Questions