In someone who has central obesity, which mechanism best explains how excess adipose tissue leads to chronic high blood glucose?

• A. Adipose-derived inflammatory cytokines impair insulin-triggered GLUT4 translocation to cell membranes, reducing peripheral glucose uptake.
• B. Fat cells directly secrete factors that cause pancreatic beta-cell failure and immediate loss of insulin production.
• C. Extra adipose tissue increases renal glucose reabsorption causing hyperglycemia.
• D. Adipose expansion increases hepatic gluconeogenesis by directly blocking glucagon signaling in the liver.

Answer: (A)