Pathophysiology: Concepts of Human Disease, 1st edition

Published by Pearson (September 18, 2020) © 2019

  • Matthew Sorenson
  • Lauretta Quinn
  • Diane Klein
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Pathophysiology: Concepts of Human Disease focuses on the human aspect of pathophysiology, acknowledging that diseases, disorders, and syndromes occur not in a vacuum, but in people - across the lifespan. Drawing on the health stories of real individuals, the authors provide the latest information in pathophysiology that is relevant to clinical practice, while empowering students with competencies that endure throughout a nursing career.

Throughout the text, the approach to pathophysiology reflects a shift of focus in healthcare from understanding diseases in their later stages to understanding risk factors and the interventions that can maintain good health and slow progression of disease in humans.

  • PART 1: FOUNDATIONS OF PATHOPHYSIOLOGY
  • 1. Introduction to the Basics of Pathophysiology
  • 2. Genetics, Genomics, and Epigenomics
  • 3. Environmental Influences on Disease and Injury
  • 4. Stress and Adaptation
  • PART 2: RISKS UNDERLYING THE LEADING CAUSES OF MORBIDITY AND MORTALITY
  • 5. Health Risks of Obesity and Physical Inactivity
  • 6. Risks Related to Substance Use Disorders
  • 7. Risks Related to Sleep Alterations
  • PART 3: FLUID, ELECTROLYTE, AND ACID-BASE IMBALANCES
  • 8. Fluid and Electrolyte Imbalances
  • 9. Acid-Base Imbalances
  • PART 4: CELL INJURY, INFLAMMATION, AND ALTERATIONS OF CELL GROWTH AND REGULATION
  • 10. Mechanisms of Cell Injury and Aging
  • 11. Inflammation
  • 12. Neoplasia
  • PART 5: INFECTION AND DISORDERS OF IMMUNITY
  • 13. Mechanisms of Infection and Host Protection
  • 14. Hypersensitivity and Autoimmune Disorders
  • 15. Immunodeficiency Disorders
  • 16. Disorders of White Blood Cells
  • PART 6: DISORDERS OF OXYGENATION
  • 17. Restrictive Lung Disorders
  • 18. Obstructive Lung Disorders
  • 19. Neoplastic, Infectious, and Pulmonary Vascular Lung Disorders
  • 20. Respiratory Failure
  • 21. Disorders of Oxygen Transport
  • PART 7: DISORDERS OF PERFUSION
  • 22. Alterations of Hemostasis
  • 23. Vascular Disorders
  • 24. Coronary Circulation Disorders
  • 25. Cardiac Structural Disorders
  • 26. Heart Failure
  • 27. Disorders of Circulation within the Central Nervous System
  • 28. Shock and Multiple Organ Dysfunction Syndrome
  • PART 8: DISORDERS OF MOOD AND COGNITION
  • 29. Disorders of Emotional Regulation
  • 30. Disorders of Neurodevelopment and Neurocognition
  • PART 9: DISORDERS OF SENSORY PERCEPTION AND THERMOREGULATION
  • 31. Disorders of Hearing, Balance, and Vision
  • 32. Pain, Neuropathy, and Headache
  • 33. Disorders of Thermoregulation
  • PART 10: DISORDERS OF MOBILITY
  • 34. Disorders Affecting Motor Function
  • 35. Acute Musculoskeletal Disorders
  • 36. Chronic Musculoskeletal Disorders
  • PART 11: DISORDERS OF ENDOCRINE REGULATION
  • 37. Diabetes Mellitus
  • 38. Thyroid, Parathyroid, and Adrenal Disorders
  • PART 12: ALTERED TISSUE INTEGRITY
  • 39. Tissue and Wound Healing
  • 40. Acute Skin Disorders
  • 41. Chronic Skin Disorders
  • PART 13: DISORDERS OF DIGESTION, METABOLISM, AND ELIMINATION
  • 42. Disorders of the Upper and Lower Gastrointestinal System
  • 43. Disorders of the Exocrine Pancreatic and Hepatobiliary Systems
  • 44. Liver Failure
  • 45. Disorders of Kidney and Urinary Tract Structure and Function
  • 46. Acute Kidney Injury and Chronic Kidney Disease
  • PART 14: DISORDERS OF SEXUALITY AND REPRODUCTION
  • 47. Disorders of the Female Reproductive System
  • 48. Disorders of the Male Reproductive System
  • 49. Sexually Transmitted Infections
  • PART 15: TRAUMA AND MULTISYSTEM CONDITIONS
  • 50. Mechanisms of Traumatic Injury
  • 51. The Pathophysiology of Primary and Secondary Traumatic Injury
  • 52. Biologic, Chemical, and Radiologic Agents of Disease
  • 53. Pathophysiology at the End of Life

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