Question 1

Which of the following best describes a transcription factor?

Accepted Answer

A protein that binds to DNA and affects the ability of RNA polymerase to transcribe a gene.

Question 2

Which of the following statements about DNA sites bound by regulatory transcription factors is correct?

Accepted Answer

They are promoters or enhancers.

Question 3

A homodimer is:

Accepted Answer

A pair of identical proteins.

Question 4

Which of the following is true about response elements?

Accepted Answer

They may be located within the gene itself.

Question 5

In comparing the effects of regulatory transcription factors that affect TFIID and those that affect mediator, which is correct?

Accepted Answer

Mediator allows binding of RNA polymerase but transcription can be prevented by transcription factors binding to silencers.

Question 6

Which of the following is a property of housekeeping genes?

Accepted Answer

They are constitutively expressed.

Question 7

Methylation of CpG islands:

Accepted Answer

Interferes directly with RNA polymerase binding.

Question 8

Which of the following best explains the interference of DNA methylation with transcription factor binding?

Accepted Answer

Methyl-CpG binding protein competes with the transcription factor for binding to methylated DNA.

Question 9

Which of the following is true about gene amplification?

Accepted Answer

It is the only alteration that involves changes in the chemical structure of the DNA.

Question 10

Which of the following pieces of DNA would you expect to be most susceptible to DNase-I digestion?

Accepted Answer

A 10nm fiber.

Question 11

A CpG island consists of about how many copies of the CG dinucleotide?

Accepted Answer

$2000$

Question 12

Which of the following is true about the poly-A tail of mRNA?

Accepted Answer

The length of the poly-A tail has a dramatic effect on RNA stability.

Question 13

Which of the following is a likely effect of RNA editing?

Accepted Answer

It can control the insertion or deletion of uracils.

Question 14

Which of the following is true about RNA editing?

Accepted Answer

It occurs in widely varied species.

Question 15

Which of the following is true about the stability of a particular mRNA?

Accepted Answer

All of the above.

Question 16

Which of the following is true about the function of receptor tyrosine kinases?

Accepted Answer

Control of the function of receptor tyrosine kinases primarily occurs at the level of posttranslational modification.

Question 17

Changes in function of which of the following proteins by posttranslational modification (such as phosphorylation or acetylation) would be likely to, in turn, affect the expression of specific genes?

Accepted Answer

Histones

Question 18

Which of the following statements about alternative splicing is correct?

Accepted Answer

All of these.

Question 19

Which of the following is true about single RNA molecules?

Accepted Answer

A single RNA molecule can encode several different proteins.

Question 20

Which of the following is true about the function of glucocorticoid response elements (GREs)?

Accepted Answer

All of these.

Regulation of Gene Expression and Epigenetics: Study Notes

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