Is the following statement true or false? Explain.
The citric acid cycle can operate in both aerobic and anaerobic conditions.

• A. True. The citric acid cycle produces ATP, which is sufficient for cellular functions even without oxygen.
• B. False. The citric acid cycle cannot operate under anaerobic conditions because it depends on the electron transport chain, which requires oxygen to regenerate NAD⁺ and FAD.
• C. True. The citric acid cycle can operate under anaerobic conditions but generates less energy than under aerobic conditions.
• D. False. The citric acid cycle does not require oxygen to convert acetyl-CoA into carbon dioxide and water during the citric acid cycle for energy release.

Answer: (B)