Create a short, evidence-based dietary plan aimed at lowering expression of pro-inflammatory cytokines in an at-risk adult. Which combination most plausibly applies nutrigenomics principles to achieve the goal?

• A. Suggest removing all dietary fats and proteins completely for two weeks as the only method to reduce cytokine gene transcription, without attention to vitamins or fiber.
• B. Advise exclusive consumption of synthetic amino acid supplements that directly insert anti-inflammatory sequences into DNA, thereby permanently turning off cytokine genes.
• C. Increase omega-3 fatty acid intake (e.g., fatty fish, flaxseed), increase fiber and phytochemical-rich fruits and vegetables, reduce saturated and trans fats and refined carbohydrates, and ensure adequate vitamin D and polyphenol intake to modulate epigenetic and signaling pathways that lower pro-inflammatory gene expression.
• D. Recommend a diet high in processed red meats, refined sugars, and trans fats because these components are known to increase DNA methylation of anti-inflammatory genes and thereby lower inflammatory cytokine expression.

Answer: (C)