Investigators examined the expression of transporter mRNA and protein produced in zebrafish homozygous for each of the alleles and obtained the results summarized here (+=present,−=absent). Does the allele associated with light color appear to be altering transcription ortranslation? Why?
Ch. 16 - How Genes Work
Chapter 16, Problem 15
The allele of the human transport protein associated with lighter skin is found almost exclusively in people with European ancestry. The other common allele for darker skin, which appears to be the ancestral allele, is found in people with African ancestry. What is a plausible explanation for how the lighter-skin allele came to be so common in those with European ancestry?
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Understand the concept of natural selection and adaptation. Natural selection is a process where individuals with traits better suited to their environment tend to survive and reproduce more than those without those traits. Over generations, these traits become more common in the population.
Consider the environmental differences between Europe and Africa. Europe generally has lower levels of sunlight compared to Africa. This difference in sunlight exposure is crucial for understanding skin color variation.
Recognize the role of vitamin D and sunlight. Vitamin D is essential for human health, and one of its sources is synthesis in the skin through exposure to sunlight. In areas with less sunlight, like Europe, lighter skin would be advantageous for more efficient synthesis of vitamin D.
Link the mutation for lighter skin to a survival advantage in Europe. A mutation causing lighter skin would allow individuals in sunlight-deficient regions to synthesize vitamin D more efficiently, thus having a selective advantage in terms of health and reproductive success.
Acknowledge the genetic drift and founder effect. Besides natural selection, these genetic mechanisms could also play a role in increasing the frequency of the lighter-skin allele among European populations. Genetic drift refers to random changes in allele frequencies, and the founder effect occurs when a new population is established by a very small number of individuals from a larger population.

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Key Concepts
Here are the essential concepts you must grasp in order to answer the question correctly.
Natural Selection
Natural selection is a process where organisms better adapted to their environment tend to survive and produce more offspring. In the context of skin color, lighter skin may have provided a selective advantage in regions with lower sunlight, facilitating better vitamin D synthesis, which is crucial for bone health and immune function.
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Natural Selection
Genetic Drift
Genetic drift refers to random changes in allele frequencies within a population, which can lead to significant differences over time, especially in small populations. The prevalence of the lighter-skin allele in European populations may have been influenced by genetic drift, particularly in isolated communities where certain traits became more common purely by chance.
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Genetic Drift
Migration and Gene Flow
Migration and gene flow involve the transfer of genetic material between populations. As humans migrated out of Africa and settled in Europe, the mixing of populations could have introduced the lighter-skin allele, which, combined with environmental factors, may have led to its increased frequency in European ancestry.
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Gene Flow
Related Practice
Textbook Question
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Textbook Question
A small portion of the human transport protein amino acid sequence is shown here. The upper sequence is associated with darker skin, and the lower sequence is associated with lighter skin. What DNA base-pair change created the light-skin form of the human protein from the gene that coded for the dark-skin form?
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Textbook Question
Researchers compared the amino acid sequences of the transport protein in zebrafish, puffer fish, mice, and humans. They found many stretches with identical sequences in all four species. Does this mean that the corresponding mRNA base sequences are also the same in these four species? Explain why or why not.
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Textbook Question
Biologists have investigated how fast pre-mRNA splicing occurs by treating cells with a toxin that blocks the production of new pre-mRNAs, then following the rate of splicing of the pre-mRNAs that were transcribed before adding the toxin. Why is addition of a toxin important in this study?
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Textbook Question
The primary cause of death from αα-amanitin poisoning is liver failure. Suppose a physician informs you that liver cells die because their rate of protein production falls below a level needed to maintain active metabolism. Given that αα-amanitin is an inhibitor of transcription, you wonder if this information is correct. Propose an experiment to determine whether the toxin also has an effect on protein synthesis.
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