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PCB 3063: General Genetics – Course Syllabus and Study Guide

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Course Overview

Introduction to General Genetics

This course provides a comprehensive introduction to genetics, covering the fundamental concepts of Mendelian, molecular, and population genetics. Students will develop a foundational understanding of genetic principles, which will be expanded upon in more advanced courses and research.

  • Key Point: Genetics is the study of heredity and variation in living organisms.

  • Key Point: The course emphasizes both classical and modern genetic concepts, including DNA structure, gene expression, and genetic engineering.

  • Example: Mendelian inheritance patterns, such as dominant and recessive traits, are explored alongside molecular mechanisms like DNA replication.

Course Description and Prerequisites

Course Description

The course introduces students to the basic principles of genetics, including Mendelian, molecular, and population genetics. It is designed for students with a background in introductory biology and chemistry.

  • Key Point: Topics include inheritance patterns, gene structure and function, and genetic variation.

  • Key Point: The course prepares students for more advanced studies in genetics and related fields.

Prerequisites

  • BSC 2010, BSC 2010L, BSC 2011, BSC 2011L, CHM 2045, CHM 2046, MAC 1105 or higher-level MAC course, or STA 2023.

Course Format

Lecture Style and Learning Platform

The course is delivered in a lecture-style format with interactive questions and discussions. Lectures are supported by the Top Hat platform and Microsoft Teams for communication and collaboration.

  • Key Point: Students are expected to engage with lecture materials and participate in discussions.

  • Key Point: Supplemental readings and assignments are provided to reinforce learning.

Student Learning Outcomes

Expected Competencies

By the end of the course, students will be able to:

  • Cohesively explain patterns of inheritance of phenotypic characters.

  • Describe nucleic acid structures.

  • Accurately explain common molecular phenomena such as replication, recombination, transcription, translation, and mutation.

  • Critically characterize various levels of gene expression and regulation.

  • Demonstrate (using examples) various techniques and uses for modern DNA technology.

  • Analyze genetic data, quantitative population genetics, and evolutionary genetics.

Course Objectives and Topics

Major Topics Covered

  • Review of mitosis and meiosis

  • Mendelian and non-Mendelian genetics

  • Variation of fitness and mutations

  • Differences between eukaryotic and prokaryotic systems

  • Nucleic acid structures

  • DNA replication and recombination

  • The Central Dogma: DNA → mRNA → protein

  • Gene expression and its regulation

  • Recombinant DNA technology, genetic engineering, and biotechnology

  • Population and evolutionary genetics

  • Quantitative genetics

  • Applications of biotechnology genetics

  • Special topics: forensics, CRISPR, and precision medicine

Required Texts and Materials

Textbook and Online Resources

  • Concepts of Genetics, 12th edition by Klug, Cummings, Spencer, Palladino, Killian (Pearson).

  • Access Pearson Tool for homework and assignments.

  • Additional readings and links may be provided via Canvas.

Grading Scale and Categories

Grading Scale

Percent of total points

Grade

97.0 – 99.99

A+

93.0 – 96.99

A

90.0 – 92.99

A-

87.0 – 89.99

B+

83.0 – 86.99

B

80.0 – 82.99

B-

77.0 – 79.99

C+

73.0 – 76.99

C

70.0 – 72.99

C-

67.0 – 69.99

D+

63.0 – 66.99

D

60.0 – 62.99

D-

0.0 – 59.99

F

Grade Categories and Weights

Assessment

Percent of Final Grade

Exam 1

15%

Exam 2

15%

Exam 3

15%

Final Exam (cumulative)

15%

Homework (Pearson)

14%

Quizzes

14%

Top Hat Questions

12%

Note: The top three scores of the four semester exams will make up 45% of the grade. The lowest score from these four exams will be dropped from calculations. The final exam will not be dropped.

Course Policies and Success Strategies

How to Succeed

  • Read assigned chapters/sections before lecture.

  • Keep up-to-date on the course material to reduce stress and improve retention.

  • Complete all assignments on time.

  • Pay attention to announcements and updates on Canvas.

  • Ask questions in class or via Canvas discussions.

Academic Integrity

  • All students are expected to adhere to university policies regarding academic honesty and integrity.

  • Use of unauthorized resources during exams or assignments is strictly prohibited.

Special Topics and Applications

Modern Applications of Genetics

The course will also cover contemporary topics such as CRISPR gene editing, forensic genetics, and precision medicine, highlighting the relevance of genetics in modern science and society.

  • Key Point: CRISPR technology allows for targeted modification of genetic material.

  • Key Point: Forensic genetics is used in criminal investigations and paternity testing.

  • Key Point: Precision medicine uses genetic information to tailor medical treatments to individual patients.

Contact and Communication

Instructor Information

  • Instructor: Dr. Ryan McClenay

  • Email: ryanmcclenay@usf.edu

  • Office Location: SMC 8307

  • Office Hours: T and R, 10:45 to 11:45 am (by appointment)

Additional info:

  • Students are encouraged to use Microsoft Teams and Canvas for course communication and collaboration.

  • Exams will focus on both cumulative and recent material, with accommodations for documented absences.

  • Homework and quizzes are administered via Pearson and Canvas, respectively.

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