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Ch.10 Acids and Bases
McMurry - Fundamentals of General, Organic, and Biological Chemistry 8th Edition
McMurry8th EditionFundamentals of General, Organic, and Biological ChemistryISBN: 9780134015187당신이 사용하는 게 아니라요?교과서 변경
모든 교과서McMurry 8th EditionCh.10 Acids and Bases문제 111a
10장, 문제 111a

Many allergy medications contain antihistamines, compounds that contain amine groups (R-NH2, where R refers to an organic functional group). Would you expect these compounds to be acidic, basic or neutral? Explain.
a. One over-the-counter product lists the active ingredient as "diphenhydramine HCl." What does this designation mean?

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Step 1: Begin by analyzing the chemical structure of amine groups (R-NH₂). Amines are nitrogen-containing compounds where the nitrogen atom has a lone pair of electrons. This lone pair allows amines to act as proton acceptors, making them basic in nature.
Step 2: Consider the designation 'diphenhydramine HCl.' The 'HCl' indicates that the compound is in its hydrochloride salt form. This is common for amine-containing drugs, as the amine group reacts with hydrochloric acid (HCl) to form a salt, which improves the compound's solubility in water.
Step 3: Understand the reaction between the amine group and HCl. The amine group (R-NH₂) acts as a base and accepts a proton (H⁺) from HCl, forming the ammonium ion (R-NH₃⁺). This process neutralizes the basicity of the amine group, resulting in a salt form.
Step 4: Evaluate the acidity, basicity, or neutrality of the compound. In its hydrochloride salt form, diphenhydramine HCl is neutral because the basic amine group has been protonated and paired with the chloride ion (Cl⁻), balancing the charge.
Step 5: Conclude that while amines are typically basic, the presence of 'HCl' in diphenhydramine HCl indicates that the compound has been converted into a neutral salt form for pharmaceutical use.

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주요 개념

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Antihistamines and Amine Groups

Antihistamines are compounds that block the action of histamine, a substance in the body that causes allergic symptoms. Many antihistamines contain amine groups (R-NH₂), which are basic due to the presence of a nitrogen atom that can accept protons. This basicity influences their interaction with biological systems and their overall pharmacological effects.
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가이드 코스
0:54
Amine Classification Example 1

Acidity and Basicity of Compounds

The acidity or basicity of a compound is determined by its ability to donate or accept protons (H⁺ ions). Compounds with amine groups are generally considered basic because they can accept protons, leading to a positive charge. Understanding this property is crucial for predicting the behavior of antihistamines in the body and their effectiveness in treating allergies.
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가이드 코스
01:04
Balancing Redox Reactions: Basic Solutions

Diphenhydramine HCl Designation

The designation 'diphenhydramine HCl' indicates that diphenhydramine is combined with hydrochloric acid to form a salt. This salt form enhances the solubility and stability of the drug, making it easier to administer and absorb in the body. The 'HCl' signifies that the diphenhydramine is in its hydrochloride form, which is common for many pharmaceutical compounds.
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가이드 코스
02:41
Buffer Solution Example
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