Calculation: During an overnight fast a subject's liver releases 12 grams of glucose into the bloodstream via glycogenolysis. Assuming a blood volume of 5.0 L, calculate the approximate increase in blood glucose concentration in mg/dL produced by that release. Show your work and final answer.

• A. Approximately 2,400 mg/dL increase, as you multiply grams by 200 and then divide by liters to obtain mg/dL.
• B. No measurable change in plasma glucose because glycogen-derived glucose is sequestered within liver cells and never reaches the systemic circulation.
• C. Approximately 240 mg/dL increase in blood glucose concentration.
• D. Approximately 24 mg/dL increase, because 12 g is negligible when distributed in 5 L of blood.

Answer: (C)