Where are the mechanoreceptors that sense stomach fullness primarily located and what is their primary neural pathway to the brain?

• A. Mechanoreceptors are spread throughout skeletal muscle and signal fullness through somatic reflex arcs that directly modulate satiety center activity.
• B. Mechanoreceptors are exclusively located in the colon and use sympathetic efferents to inform the frontal cortex about satiety.
• C. Mechanoreceptors are located in the stomach and small intestine wall and signal the brain primarily via vagal afferent pathways to hypothalamic centers.
• D. Mechanoreceptors are located in the liver capsule and communicate fullness through hepatic portal hormones rather than neural routes.

Answer: (C)