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Protein-Related Disorders
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Protein-Related Disorders
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6. Proteins / Protein-Related Disorders / Problem 4
Problem 4
Which mechanism best explains why insufficient dietary protein leads to peripheral edema in kwashiorkor?
A
Lack of protein intake leads to hyperalbuminemia that paradoxically pulls fluid out of the vascular space and causes visible swelling due to tissue rupture.
B
Low synthesis of plasma proteins (especially albumin) reduces plasma oncotic pressure, allowing fluid to move from the vascular compartment into interstitial spaces and cause edema.
C
Protein deficiency increases capillary hydrostatic pressure directly by stimulating the renin-angiotensin-aldosterone system, which is the sole cause of edema in kwashiorkor.
D
Dietary protein deficiency raises the pH of interstitial fluid, causing osmotic water attraction into tissues independent of oncotic forces.
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