22. Carboxylic Acid Derivatives: NAS
Nucleophilic Acyl Substitution
Problem 15n
Textbook Question
Textbook QuestionThe reaction of a nitrile with an alcohol in the presence of a strong acid forms an N-substituted amide. This reaction, known as the Ritter reaction, does not work with primary alcohols. The Ritter reaction RC≡N + R'OH HCl—> RC=O(NHR') c. How does the Ritter reaction differ from the acid-catalyzed hydrolysis of a nitrile to form an amide?
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