Ch. 21 - Amino Acids, Peptides, and Proteins

Bruice8th EditionOrganic ChemistryISBN: 9780135213711Non è quello che usi tu?Cambia libro di testo

Bruice 8th Edition

Ch. 21 - Amino Acids, Peptides, and Proteins

Problema 28

Capitolo 21, Problema 28

Which bonds in the backbone of a peptide can rotate freely?

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Understand the structure of a peptide backbone: A peptide backbone consists of repeating units of amide bonds (-CONH-) connecting amino acids. The backbone includes the alpha carbon (Cα), the carbonyl carbon (C=O), and the amide nitrogen (N-H).

Recognize the rigidity of the peptide bond: The peptide bond itself (between the carbonyl carbon and the amide nitrogen) is planar and rigid due to resonance, which gives it partial double-bond character. This means the peptide bond cannot rotate freely.

Identify the bonds adjacent to the peptide bond: The bonds that can rotate freely are the single bonds on either side of the peptide bond. These include the bond between the alpha carbon (Cα) and the carbonyl carbon (C=O), and the bond between the alpha carbon (Cα) and the amide nitrogen (N).

Understand the significance of phi (ϕ) and psi (ψ) angles: The rotation around the bond between the alpha carbon and the amide nitrogen is described by the phi (ϕ) angle, while the rotation around the bond between the alpha carbon and the carbonyl carbon is described by the psi (ψ) angle. These rotations allow for flexibility in the peptide backbone.

Note the constraints on rotation: While these bonds can rotate freely, steric hindrance and interactions between side chains and backbone atoms can limit the range of rotation in real peptide structures.

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Peptide Bond

A peptide bond is a covalent bond formed between the carboxyl group of one amino acid and the amino group of another, resulting in the release of a water molecule. This bond is characterized by partial double-bond character due to resonance, which restricts its rotation and contributes to the rigidity of the peptide backbone.

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Percorso guidato

1:24

Peptides Example 1

Phi (φ) and Psi (ψ) Angles

In the context of peptide bonds, the phi (φ) and psi (ψ) angles refer to the torsional angles around the bonds connecting the nitrogen to the alpha carbon and the alpha carbon to the carbonyl carbon, respectively. These angles can rotate freely, allowing for the conformational flexibility of the peptide backbone, which is crucial for protein folding and function.

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06:20

Alternative MO Notation for Dienes

Conformational Flexibility

Conformational flexibility in peptides refers to the ability of the peptide chain to adopt various spatial arrangements due to the rotation around certain bonds. This flexibility is essential for the biological activity of proteins, as it enables them to change shape and interact with other molecules, facilitating processes such as enzyme catalysis and receptor binding.

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03:29

Understanding what a conformer is.

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