교과서 질문
Give an example of a protein that has quaternary structure. How many polypeptide chains are present in this protein?
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Ch.18 Amino Acids and Proteins
McMurry8th EditionFundamentals of General, Organic, and Biological ChemistryISBN: 9780134015187
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TOC.tableOfContents
- Ch.1 Matter and Measurements27
- Ch.2 Atoms and the Periodic Table20
- Ch.3 Ionic Compounds8
- Ch.4 Molecular Compounds23
- Ch.5 Classification & Balancing of Chemical Reactions12
- Ch.6 Chemical Reactions: Mole and Mass Relationships28
- Ch.7 Chemical Reactions: Energy, Rate and Equilibrium64
- Ch.8 Gases, Liquids and Solids24
- Ch.9 Solutions52
- Ch.10 Acids and Bases25
- Ch.11 Nuclear Chemistry22
- Ch.12 Introduction to Organic Chemistry: Alkanes57
- Ch.13 Alkenes, Alkynes, and Aromatic Compounds47
- Ch.14 Some Compounds with Oxygen, Sulfur, or a Halogen50
- Ch.15 Aldehydes and Ketones45
- Ch.16 Amines42
- Ch.17 Carboxylic Acids and Their Derivatives57
- Ch.18 Amino Acids and Proteins82
- Ch.19 Enzymes and Vitamins63
- Ch.20 Carbohydrates44
- Ch.21 The Generation of Biochemical Energy65
- Ch.22 Carbohydrate Metabolism45
- Ch.23 Lipids42
- Ch.24 Lipid Metabolism33
- Ch.25 Protein and Amino Acid Metabolism24
- Ch.26 Nucleic Acids and Protein Synthesis45
McMurry8th EditionFundamentals of General, Organic, and Biological ChemistryISBN: 9780134015187당신이 사용하는 게 아니라요?교과서 변경
18장, 문제 87b
How do the following interactions help to stabilize the tertiary and quaternary structure of a protein? Give an example of a pair of amino acids that could give rise to each interaction.
b. Disulfide bonds
검증된 단계별 안내1
Understand the concept of disulfide bonds: Disulfide bonds are covalent bonds formed between the sulfur atoms of two cysteine amino acid residues. These bonds help stabilize the three-dimensional structure of proteins by creating strong links between different parts of the polypeptide chain or between different polypeptide chains in a protein complex.
Recognize the role of disulfide bonds in protein structure: In the tertiary structure, disulfide bonds stabilize the folding of a single polypeptide chain by connecting distant regions of the chain. In the quaternary structure, they can stabilize the association of multiple polypeptide chains into a functional protein complex.
Identify the amino acids involved: The amino acid cysteine is the only one capable of forming disulfide bonds due to the presence of a thiol group (-SH) in its side chain. When two cysteine residues come into close proximity, their thiol groups can undergo oxidation to form a disulfide bond (S-S).
Provide an example: A pair of cysteine residues within a single polypeptide chain or between two chains can form a disulfide bond. For instance, in the hormone insulin, disulfide bonds link the A and B chains of the protein, contributing to its quaternary structure.
Summarize the stabilization effect: Disulfide bonds contribute to the stability of the protein by reducing the flexibility of the polypeptide chain and maintaining the protein's functional conformation under various environmental conditions, such as changes in pH or temperature.
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주요 개념
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Disulfide Bonds
Disulfide bonds are covalent linkages formed between the sulfur atoms of two cysteine amino acids. These bonds play a crucial role in stabilizing the tertiary and quaternary structures of proteins by creating strong connections that help maintain the protein's three-dimensional shape. For example, when two cysteine residues are in proximity, they can undergo oxidation to form a disulfide bond, which significantly enhances the structural integrity of the protein.
추천 영상:
가이드 코스
01:50
Bond Energy
Tertiary Structure
The tertiary structure of a protein refers to its overall three-dimensional shape, formed by the folding and interactions of its polypeptide chain. This structure is stabilized by various interactions, including hydrogen bonds, ionic bonds, hydrophobic interactions, and disulfide bonds. The specific arrangement of amino acids and their side chains determines how the protein folds, which is essential for its function.
추천 영상:
가이드 코스
2:07Tertiary Protein Structure Concept 1
Quaternary Structure
Quaternary structure is the assembly of multiple polypeptide chains into a single functional protein complex. This structure is stabilized by various interactions, including disulfide bonds, which can link different polypeptide chains together. An example is hemoglobin, which consists of four polypeptide subunits, and the interactions between these subunits are critical for its ability to transport oxygen in the blood.
추천 영상:
가이드 코스
3:26Quaternary Protein Structure Concept 1
관련 실천
교과서 질문
Explain how a protein is denatured by the following:
a. Heat
교과서 질문
How do the following noncovalent interactions help to stabilize the tertiary and quaternary structure of a protein? Give an example of a pair of amino acids that could give rise to each interaction.
a. Hydrophobic interactions
914
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교과서 질문
What level of protein structure is determined by the following:
a. Peptide bonds between amino acids?
1051
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교과서 질문
What level of protein structure is determined by the following:
b. Hydrogen bonds between backbone carbonyl oxygen atoms and hydrogen atoms attached to backbone nitrogen atoms?
826
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교과서 질문
Explain how a protein is denatured by the following:
b. Strong acids