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Ch.18 Amino Acids and Proteins
McMurry - Fundamentals of General, Organic, and Biological Chemistry 8th Edition
McMurry8th EditionFundamentals of General, Organic, and Biological ChemistryISBN: 9780134015187당신이 사용하는 게 아니라요?교과서 변경
모든 교과서McMurry 8th EditionCh.18 Amino Acids and Proteins문제 33
18장, 문제 33

If the same peptide found in Problem 18.32 is subjected to acid hydrolysis, how many fragments will result? Why?
Ala-Phe-Lys-Cys-Gly-Asp-Arg-Leu-Leu-Phe-Gly-Ala

검증된 단계별 안내
1
Identify the peptide sequence from Problem 18.32 (not provided here, but you would need to refer to it to proceed). A peptide is a chain of amino acids linked by peptide bonds.
Understand that acid hydrolysis breaks peptide bonds, which are the covalent bonds between the carboxyl group of one amino acid and the amino group of the next amino acid.
Count the number of peptide bonds in the peptide sequence. The number of peptide bonds is equal to the number of amino acids in the peptide minus one.
Realize that during acid hydrolysis, each peptide bond is cleaved, resulting in individual amino acids as fragments. Therefore, the number of fragments will equal the number of amino acids in the peptide.
Conclude that the number of fragments corresponds to the total number of amino acids in the peptide, and this happens because acid hydrolysis completely breaks all peptide bonds.

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주요 개념

질문에 올바르게 답하기 위해 반드시 이해해야 하는 핵심 개념들은 다음과 같습니다.

Acid Hydrolysis

Acid hydrolysis is a chemical reaction where water and an acid are used to break down compounds. In the context of peptides, this process cleaves the peptide bonds between amino acids, resulting in the release of individual amino acids or smaller peptide fragments. Understanding this reaction is crucial for predicting the outcome of peptide fragmentation.
추천 영상:
가이드 코스
1:12
Acidic Hydrolysis Concept 1

Peptide Structure

Peptides are short chains of amino acids linked by peptide bonds. The sequence and number of amino acids determine the peptide's properties and behavior during hydrolysis. Knowing the specific structure of the peptide in question is essential to accurately predict how many fragments will be produced after acid hydrolysis.
추천 영상:
가이드 코스
3:07
Peptides Concept 1

Fragmentation Analysis

Fragmentation analysis involves examining the products formed after a chemical reaction, such as hydrolysis. By analyzing the resulting fragments, one can determine the number of distinct pieces generated from the original peptide. This concept is vital for understanding the implications of the hydrolysis process on the peptide's composition.
추천 영상:
가이드 코스
06:11
Dimensional Analysis
관련 실천
교과서 질문

Both α-keratin and tropocollagen have helical secondary structure. How do these molecules differ in (a) amino acid composition and (b) three-dimensional structure?

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교과서 질문

Draw the structure of the following amino acids, dipeptides, and tripeptides at low pH (pH 1) and high pH (pH 14). At each pH, assume that all functional groups that might do so are ionized.

a. Val

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교과서 질문

Another endoprotease is trypsin. Trypsin hydrolyzes peptide bonds on the carboxyl side of lysine and arginine. If the following peptide sequence is hydrolyzed by trypsin, how many fragments will there be? Use the three-letter amino acid abbreviations to write the fragments out.

 Ala-Phe-Lys-Cys-Gly-Asp-Arg-Leu-Leu-Phe-Gly-Ala

교과서 질문

Draw the structure of the following amino acids, dipeptides, and tripeptides at low pH (pH 1) and high pH (pH 14). At each pH, assume that all functional groups that might do so are ionized.

e. Gln-Ala-Asn

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교과서 질문

For each of the conjugated proteins described, identify to which class of conjugated protein it belongs.

c. Phosphate groups are attached to this protein.

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교과서 질문

Draw the structure of the following amino acids, dipeptides, and tripeptides at low pH (pH 1) and high pH (pH 14). At each pH, assume that all functional groups that might do so are ionized.

d. Glu-Asp

195
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