Nail–patella syndrome is an autosomal disorder affecting the shape of nails on fingers and toes as well as the structure of kneecaps. The pedigree below shows the transmission of nail–patella syndrome in a family along with ABO blood type.
Does this family give evidence of genetic linkage between nail–patella syndrome and ABO blood group? Why or why not?

Question

Nail–patella syndrome is an autosomal disorder affecting the shape of nails on fingers and toes as well as the structure of kneecaps. The pedigree below shows the transmission of nail–patella syndrome in a family along with ABO blood type.

Does this family give evidence of genetic linkage between nail–patella syndrome and ABO blood group? Why or why not?

Pedigree chart illustrating the inheritance of nail–patella syndrome and ABO blood types in a family.

Does this family give evidence of genetic linkage between nail–patella syndrome and ABO blood group? Why or why not?

Accepted Answer

Hey, everyone. Let's take a look at this question together for parents who are carriers of certain genetic disorders and don't want to pass on that genetic disorder to their Children. What is the importance of knowing the gender of an unborn child? Is it answer choice. A male Children are more likely to have autism defects show up in their phenotypes. Answer choice. B female Children are more likely to have autism defects show up in their phenotypes. Answer choice C male Children are more likely to have X linked traits show up in their phenotypes or answer choice. D none of the above. Let's work this problem out together to try to figure out which of the following answer choices is the correct answer. So when it comes to certain genetic disorders, we know that X linked rates are passed from mother, two son. And we know that males um one X chromosome, which is important because having one X means there is a lower yeah, of masking that great. And because of this, we know that male Children are more likely to have excellent traits show up in their phenotypes. So answer choice C is the correct answer because men are more likely to inherit those excellent characteristics. Since the ex link traits are passed from mother to son. And because males only have that one X chromosome, having the one X chromosome means there is a lower chance of masking that trait. For example, in females, since they have two X chromosomes, they could have a recessive disorder that gets masked by having a dominant normal allele on the other X chromosome. Or in this case, because the males only have that one X chromosome, there is a lower chance of being able to mask that trait. So male Children are more likely to have xli traits show up in their phenotypes making answer choice c the correct answer. And it is important to know the gender of that unborn child in order to determine if there is a family history of excellent traits because of that. I hope you found this video to be helpful. Thank you and goodbye.

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Key Concepts

Genetic Linkage

Pedigree Analysis

Autosomal Inheritance