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Ch. 10 - Eukaryotic Chromosome Abnormalities and Molecular Organization
Sanders - Genetic Analysis: An Integrated Approach 3rd Edition
Sanders3rd EditionGenetic Analysis: An Integrated ApproachISBN: 9780135564172Not the one you use?Change textbook
Chapter 10, Problem 30

Human chromosome 5 and the corresponding chromosomes from chimpanzee, gorilla, and orangutan are shown here. Describe any structural differences you see in the other primate chromosomes in relation to the human chromosome.

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1
Examine the provided images or diagrams of chromosome 5 from humans, chimpanzees, gorillas, and orangutans. Look for structural differences such as inversions, deletions, duplications, or translocations.
Identify any differences in the length of the chromosomes. For example, check if the primate chromosomes are shorter or longer compared to the human chromosome 5.
Look for variations in banding patterns (if karyotype images are provided). Banding patterns can indicate structural rearrangements such as inversions or translocations.
Determine if there are any centromere position differences. For instance, check if the centromere is metacentric (centered) or acrocentric (closer to one end) in the primate chromosomes compared to the human chromosome.
Note any additional features such as the presence or absence of specific regions (e.g., telomeric sequences or heterochromatic regions) that may differ between the human and primate chromosomes.

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Key Concepts

Here are the essential concepts you must grasp in order to answer the question correctly.

Chromosomal Structure

Chromosomal structure refers to the organization of DNA within a chromosome, including the arrangement of genes, regulatory elements, and non-coding regions. Differences in chromosomal structure among species can include variations in the number of chromosomes, the presence of additional segments, or rearrangements such as inversions and translocations. Understanding these structural differences is crucial for comparing genetic material across species.
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Chromosome Structure

Comparative Genomics

Comparative genomics is the field of study that involves comparing the genomes of different species to identify similarities and differences. This approach helps in understanding evolutionary relationships and functional genomics. By analyzing the chromosomal differences between humans and other primates, researchers can infer evolutionary adaptations and the genetic basis of traits specific to each species.
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Genomics Overview

Evolutionary Biology

Evolutionary biology examines the processes that drive the diversity of life on Earth, including natural selection, genetic drift, and speciation. Structural differences in chromosomes can provide insights into evolutionary history and the mechanisms by which species diverge. By studying these differences, scientists can better understand how genetic changes contribute to the adaptation and survival of primates in their respective environments.
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Related Practice
Textbook Question

A small population of deer living on an isolated island is separated for many generations from a mainland deer population. The populations retain the same number of chromosomes but hybrids are infertile. One chromosome (shown here) has a different banding pattern in the island population than in the mainland population.

Suppose that 40% of all meioses in mainland–island hybrids involve recombination somewhere in the chromosome region between q2.1 and p2. What proportion of the gametes of hybrid deer are viable? What is the cause of the decreased proportion of viable gametes in hybrids relative to the parental populations?

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Textbook Question

A eukaryote with a diploid number of 2n=6 carries the chromosomes shown below and labeled (a) to (f).

Carefully examine and redraw these chromosomes in any valid metaphase I alignment. Draw and label the metaphase plate, and label each chromosome with its assigned letter. 

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Textbook Question

A eukaryote with a diploid number of 2n=6 carries the chromosomes shown below and labeled (a) to (f).


Explain how you determined the correct alignment of homologous chromosomes on opposite sides of the metaphase plate. 

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Textbook Question

For the following crosses, determine as accurately as possible the genotypes of each parent, the parent in whom nondisjunction occurs, and whether nondisjunction takes place in the first or second meiotic division. Both color blindness and hemophilia, a blood-clotting disorder, are X-linked recessive traits. In each case, assume the parents have normal karyotypes.

A man and a woman who each has the wild-type phenotype have a son with Klinefelter syndrome (XXY) who has hemophilia.

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Textbook Question

For the following crosses, determine as accurately as possible the genotypes of each parent, the parent in whom nondisjunction occurs, and whether nondisjunction takes place in the first or second meiotic division. Both color blindness and hemophilia, a blood-clotting disorder, are X-linked recessive traits. In each case, assume the parents have normal karyotypes.

A man who is color blind and a woman who is wild type have a son with Jacob syndrome (XYY) who has hemophilia.

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Textbook Question

For the following crosses, determine as accurately as possible the genotypes of each parent, the parent in whom nondisjunction occurs, and whether nondisjunction takes place in the first or second meiotic division. Both color blindness and hemophilia, a blood-clotting disorder, are X-linked recessive traits. In each case, assume the parents have normal karyotypes.

A color-blind man and a woman who is wild type have a daughter with Turner syndrome (XO) who has normal color vision and blood clotting.

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