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Ch. 2 - Transmission Genetics
Sanders - Genetic Analysis: An Integrated Approach 3rd Edition
Sanders3rd EditionGenetic Analysis: An Integrated ApproachISBN: 9780135564172Not the one you use?Change textbook
All textbooksSanders 3rd EditionCh. 2 - Transmission GeneticsProblem 49a
Chapter 2, Problem 49a

Go to the OMIM website (http://www.ncbi.nlm.nih.gov/omim) and locate the Search button at the top of the page. Use the search function to look up, one by one, the following three human hereditary diseases that are relatively common in certain populations: 'Tay–Sachs disease' (select OMIM number 272800 from the search results list); 'cystic fibrosis' (select OMIM number 602421 from the search results list); and 'sickle cell anemia' (select OMIM 603903 from the search results list). For each of these diseases, look through the information and provide the following details:
On which chromosome is the gene for the disease located?

Verified step by step guidance
1
Step 1: Navigate to the OMIM website by visiting http://www.ncbi.nlm.nih.gov/omim.
Step 2: Locate the Search button at the top of the page and click on it to access the search functionality.
Step 3: Use the search bar to look up 'Tay–Sachs disease' and select OMIM number 272800 from the search results list. Review the information provided to identify the chromosome where the gene for Tay–Sachs disease is located.
Step 4: Repeat the search process for 'cystic fibrosis' and select OMIM number 602421 from the search results list. Examine the details to determine the chromosome associated with the gene for cystic fibrosis.
Step 5: Perform the search for 'sickle cell anemia' and select OMIM number 603903 from the search results list. Analyze the information to find the chromosome where the gene for sickle cell anemia is located.

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Key Concepts

Here are the essential concepts you must grasp in order to answer the question correctly.

Chromosomal Location

Chromosomal location refers to the specific position of a gene on a chromosome. Each human chromosome is numbered and contains numerous genes, which can be identified by their unique locations. Understanding where a gene is located is crucial for studying its function, inheritance patterns, and the implications of mutations associated with hereditary diseases.
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Chromosome Structure

Hereditary Diseases

Hereditary diseases are genetic disorders that are passed down from parents to offspring through genes. These diseases can result from mutations in a single gene or multiple genes and can vary in their expression and severity. Examples include Tay-Sachs disease, cystic fibrosis, and sickle cell anemia, each linked to specific genetic mutations and chromosomal locations.
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Mendel's Laws

OMIM Database

The Online Mendelian Inheritance in Man (OMIM) database is a comprehensive resource that catalogs human genes and genetic disorders. It provides detailed information about the genetic basis of diseases, including their chromosomal locations, inheritance patterns, and clinical features. Researchers and healthcare professionals use OMIM to access up-to-date genetic information for various hereditary conditions.
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Related Practice
Textbook Question

A pea plant that has the genotype RrGgwwdd is crossed to a plant that has the rrGgWwDd genotype. The R gene controls round versus wrinkled seed, the G gene controls yellow versus green seed, the W gene controls purple versus white flower, and the D gene controls tall versus short plants. Determine the following;


What proportion of the progeny are expected to have the genotype RrGGwwDd?

431
views
Textbook Question

A pea plant that has the genotype RrGgwwdd is crossed to a plant that has the rrGgWwDd genotype. The R gene controls round versus wrinkled seed, the G gene controls yellow versus green seed, the W gene controls purple versus white flower, and the D gene controls tall versus short plants. Determine the following;


What proportion of the progeny are expected to have the genotype rrggwwdd?

486
views
Textbook Question

A pea plant that has the genotype RrGgwwdd is crossed to a plant that has the rrGgWwDd genotype. The R gene controls round versus wrinkled seed, the G gene controls yellow versus green seed, the W gene controls purple versus white flower, and the D gene controls tall versus short plants. Determine the following:

What proportion of the progeny are expected to be round, yellow, purple, and tall?

495
views
Textbook Question

Go to the OMIM website (http://www.ncbi.nlm.nih.gov/omim) and locate the Search button at the top of the page. Use the search function to look up, one by one, the following three human hereditary diseases that are relatively common in certain populations: 'Tay–Sachs disease' (select OMIM number 272800 from the search results list); 'cystic fibrosis' (select OMIM number 602421 from the search results list); and 'sickle cell anemia' (select OMIM 603903 from the search results list). For each of these diseases, look through the information and provide the following details:

What gene is mutated in the disease?

677
views
Textbook Question

Go to the OMIM website (http://www.ncbi.nlm.nih.gov/omim) and locate the Search button at the top of the page. Use the Search function to look up, one by one, the following three human hereditary diseases that are relatively common in certain populations: 'Tay–Sachs disease' (select OMIM number 272800 from the search results list); 'cystic fibrosis' (select OMIM number 602421 from the search results list); and 'sickle cell anemia' (select OMIM 603903 from the search results list). For each of these diseases, look through the information and provide the following details:

Briefly describe the disease.

438
views
Textbook Question

Go to the OMIM website (http://www.ncbi.nlm.nih.gov/omim) and locate the Search button at the top of the page. Use the search function to look up, one by one, the following three human hereditary diseases that are relatively common in certain populations: 'Tay–Sachs disease' (select OMIM number 272800 from the search results list); 'cystic fibrosis' (select OMIM number 602421 from the search results list); and 'sickle cell anemia' (select OMIM 603903 from the search results list). For each of these diseases, look through the information and provide the following details:

In which population(s) does the disease most commonly occur?

438
views