Go online to the Online Mendelian Inheritance of Man (OMIM) website. Look up the following genetic conditions and answer the questions posed about them.
Look up Tay–Sachs disease (TSD), OMIM number 272800, and give the name and abbreviation of the affected gene and the chromosome location of the gene.

Verified step by step guidance

1. Go to the Online Mendelian Inheritance in Man (OMIM) website at https://omim.org/.
2. Use the search bar on the OMIM homepage to enter the OMIM number '272800' or the disease name 'Tay–Sachs disease'.
3. Navigate to the Tay–Sachs disease entry page that appears in the search results.
4. On the Tay–Sachs disease page, locate the section that lists the gene(s) associated with the condition. Identify the gene name and its standard abbreviation.
5. Find the chromosome location information for the gene, which is usually provided as a cytogenetic band (e.g., 15q23) or a specific chromosome number and region.

Key Concepts

Online Mendelian Inheritance in Man (OMIM) Database

OMIM is a comprehensive, authoritative online database cataloging human genes and genetic disorders. It provides detailed information about gene functions, mutations, and associated phenotypes, making it an essential tool for genetic research and clinical diagnosis.

Gene Nomenclature and Abbreviations

Genes are identified by standardized names and abbreviations that reflect their function or discovery history. Understanding gene symbols helps in accurately locating and referencing specific genes, such as HEXA for Tay–Sachs disease, facilitating clear communication in genetics.

Chromosomal Location of Genes

Each gene resides at a specific position on a chromosome, described by chromosome number and locus. Knowing the chromosomal location, like HEXA on chromosome 15 for Tay–Sachs, is crucial for genetic mapping, diagnosis, and understanding inheritance patterns.