Name the coenzyme produced during the conversion of pyruvate to acetyl CoA.

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All right. Hello everyone. So this question is a true or false and to correct the statement, if it is false, the coenzyme nah is oxidized during the conversion of pyruvate to lactate. So first, let's talk a little bit about the fates of pyruvate because pyruvate is an incredibly important metabolic intermediate that goes through multiple different pathways, multiple different metabolic pathways. So for our purposes, let's discuss two main ones. The first of which is the conversion of pyruvate into lactate. And this is called anaerobic respiration, which means that there's no oxygen consumed here or no oxygen required. Now, on the other hand, we can convert pate into a PSEO coet, which is another metabolic intermediate and this is aerobic. It does use oxygen. So here during the conversion of pyruvate into aceto koa or actually lactate because we're focusing on lactate for the question during the conversion of pyruvate into lactate in the absence of oxygen because this is anaerobic respiration. The enzyme responsible for this is called liked it dehydrogenase. So just to repeat that lactate dehydrogenase is the enzyme responsible for converting pyruvate to lactate in the absence of oxygen. So here, because this is a redox reaction. A cofactor is necessary such as an A DH. Now, during the reaction, we're starting off with an A DH, right? And it's converted after the reaction into N AD positive. So when talking about redox chemistry back in general, chem, I'm not sure which acronym you might have used, but I was taught the acronym Oil Rig, which means that oxidation is the loss of electrons and reduction is the gain of electrons. So going back to this fact, right, that N A DH is converted into N ad positive N ad positive has a positive charge, right? Whereas N A DH is neutral, so to become more positive, you have to lose electrons. Right? Oxidation is the loss of an electron, which means that N A DH was in fact oxidized to N AD positive. And so this means that the statement provided was true, right? The coenzyme N A DH is oxidized during the conversion of pyruvate lactate. And for your information, because anaerobic conditions don't actually produce a tp from pyruvate. The N AD positive that's generated is essential to produce more glyceraldehyde three phosphate and produce some at P but not the amount that you normally would get during aerobic conditions. So there you have it. And so with that being said, thank you so very much for watching and I hope you found this helpful

Name the coenzyme produced during the conversion of pyruvate to acetyl CoA.

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Key Concepts

Pyruvate Decarboxylation

Coenzyme A (CoA)

NAD+ and NADH