How do the following interactions help to stabilize the tertiary and quaternary structure of a protein? Give an example of a pair of amino acids that could give rise to each interaction.
b. Disulfide bonds

Question

How do the following interactions help to stabilize the tertiary and quaternary structure of a protein? Give an example of a pair of amino acids that could give rise to each interaction.

b. Disulfide bonds

Accepted Answer

All right. Hi everyone. So this question is asking us which interaction stabilizes the tertiary and co ordinary structures of proteins by covalent linking two separate polypeptide chains or by forming a loop in the chain provide an example of a pair of amino acids that will form this interaction. Option. A says hydrogen bonding, thyroxine and thine will form this interaction. Option B says ionic interaction, two lysine residues will form this interaction. Option C says hydrophobic interaction, Benno alanine and lucine will form this interaction. And option D says disulfide bridge two cysteine residues will form this interaction. So for this question, recall first and foremost that the tertiary and ordinary structures of proteins are dictated by interactions between individual amino acid side chains. Now, there are four different interactions that we study here. We have ionic interaction, hydrophobic interactions, hydrogen bonding and we have the formation of what are called disulfide bridges. Now recall that ionic interactions are interactions that form between two amino acid side chains that have opposite charges. So when one is negative and the other is positive, referring to their charge, then those two side chains participate in an ionic interaction. By contrast, a hydrophobic interaction takes place between two amino acids that have nonpolar side chains. This is because of the London dispersion forces that are prevalent in nonpolar compounds. Up. Next, we have hydrogen bonding. Now, each bonding for short involves amino acid side chains that are neutral and contain hydrogen atoms bound to highly electron elements such as oxygen, nitrogen or fluorine. And last but not least, we have the formation of a disulfide bridge in which two atoms of sulfur from separate residues combined together. Hence the term disulfide. Now recall also that of the four interactions we just mentioned there is only one covaid interaction because notice how the question is specifically mentioning a covalent linkage between the two amino acid side chains. And that is the disulfide bridge recall that a disulfide bridge is the only covalent interaction of the ones observed among amino acid side chains. And there's a very specific criteria to disulfide bridge formation if you will, because the formation of a disulfide bridge requires two residues of cystine cysteine is the only amino acid that can participate in a disulfide bridge. And the reason for this is because of its structure, recall it Sistine as a side chain that contains a thiol group or sh an sh group at the very end of the side chain. When the two thiol groups of separate cysteine residues combine, they create the covalent bond between sulfur atoms. So therefore, our answer here is going to be option d in the multiple choice because the interaction that stabilizes the tertiary and ordinary structures of proteins by Coly linking the two polypeptide genes or by forming a loop is the disulfide bridge and two cysteine residues will form this interaction. And so with that being said, thank you so very much for watching and I hope you found this helpful.

How do the following interactions help to stabilize the tertiary and quaternary structure of a protein? Give an example of a pair of amino acids that could give rise to each interaction.
b. Disulfide bonds

Verified video answer for a similar problem:

Key Concepts

Disulfide Bonds

Tertiary Structure

Quaternary Structure

How do the following interactions help to stabilize the tertiary and quaternary structure of a protein? Give an example of a pair of amino acids that could give rise to each interaction.b. Disulfide bonds

Verified video answer for a similar problem:

Key Concepts

Disulfide Bonds

Tertiary Structure

Quaternary Structure

How do the following interactions help to stabilize the tertiary and quaternary structure of a protein? Give an example of a pair of amino acids that could give rise to each interaction.
b. Disulfide bonds