Go to the website http://www.ncbi.nlm.nih.gov/omim and enter 'Lynch syndrome' in the Search box at the top of the page. From the list of options given, select '#120435—Lynch Syndrome.' Use the information you retrieve to answer the following questions. What are the approximate rates of cancer that develop in people carrying a mutation of one of these genes?

Question

Accepted Answer

Hi, everyone. Welcome back. Let's look at our next question. Identify which of the following is not a hallmark of cancer cells. Choice. A sustained cell proliferation. B, angiogenesis, induction c inactivation of invasion and metastasis or d immune system. Avoidance. Well, let's think about how cancer cells work. They have uncontrolled cell growth and division. They traveled to new places and conform new tumors and managed to avoid the immune system which might otherwise destroy them. Let's look through our answer choices and see which one would not be characteristic of a cancer cell. And that's going to be choice c in activation of invasion and metastasis. Instead, you would see activation of both of these things and a malignant cancer because you have, it invades other tissues, origin cells break off from the original tumor and invade other tissues or organs in the body and then begin to grow and proliferate there causing metastasis, spread to other areas of the body. We'll just look through our other answer choices to understand why they're not correct choice. A sustained cell proliferation that is a hallmark of cancer cells. They continue growing, they continue dividing even when they should stop So choice A is not correct. Choice B says angiogenesis induction, angiogenesis is the growth of new blood vessels. Cancer cells have a robust blood supply cause lots of growth of blood vessels. In fact, um several cancer drugs specifically target areas of increased blood vessel production as a way to target cancer cells or tumors. So choice B is a characteristic of cancer cells and therefore, is not our answer. And finally to the immune system, avoidance, obviously, the immune system will be trying to destroy harmful things. And cancer cells have mechanisms to avoid being recognized and attacked by the immune system. The primary one of course, being that they come from the person's own body and therefore not recognized as foreign cells. So choice d also a hallmark of cancer cells and not our answer. So the answer choice that is not characteristic of cancer cells is choice C in activation of invasion and metastasis. See you in the next video.

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Key Concepts

Lynch Syndrome and Its Genetic Basis

Cancer Penetrance in Mutation Carriers

Using OMIM Database for Genetic Information