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Ch. 14 - Analysis of Gene Function via Forward Genetics and Reverse Genetics
Sanders - Genetic Analysis: An Integrated Approach 3rd Edition
Sanders3rd EditionGenetic Analysis: An Integrated ApproachISBN: 9780135564172Not the one you use?Change textbook
Chapter 14, Problem C.9d

Go to the website http://www.cancer.gov and select 'Cancer Types' on the top menu bar. Scroll down to 'Breast Cancer' and click. Select 'Cases & Prevention' from the options. Click 'More information' and select 'BRCA Mutations: Cancer Risk and Genetic Testing'. Use the information on this page to answer the following questions. Are there measures a woman with a positive result can take to lessen her chances of developing cancer or to catch a cancer early in its development?

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This question is about understanding genetic risk factors and preventive measures related to BRCA mutations, which are linked to breast cancer risk.
First, recognize that BRCA1 and BRCA2 are genes where certain mutations can significantly increase the risk of breast and ovarian cancers.
Next, explore the information on the specified website section about BRCA mutations, focusing on recommended strategies for women who test positive for these mutations.
Identify the preventive measures mentioned, which may include increased surveillance (such as more frequent mammograms or MRI scans), lifestyle changes, chemoprevention (using medications to reduce risk), and prophylactic surgeries (such as mastectomy or oophorectomy) to reduce cancer risk.
Finally, understand that early detection strategies aim to catch cancer at an early, more treatable stage, while preventive surgeries and medications aim to lower the overall risk of developing cancer.

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Key Concepts

Here are the essential concepts you must grasp in order to answer the question correctly.

BRCA Gene Mutations and Cancer Risk

BRCA1 and BRCA2 are genes that produce proteins responsible for repairing DNA damage. Mutations in these genes can significantly increase a woman's risk of developing breast and ovarian cancers. Understanding these mutations helps assess individual cancer risk and guides decisions about prevention and screening.
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Preventive Measures for High-Risk Individuals

Women with positive BRCA mutations can take preventive actions such as increased surveillance, chemoprevention, or risk-reducing surgeries like mastectomy or oophorectomy. These measures aim to lower the chance of cancer development or detect it early when treatment is more effective.
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Early Detection and Screening Strategies

Early detection involves regular screening methods like mammograms, MRI, and clinical breast exams, especially for high-risk women. These strategies help identify cancer at an early stage, improving treatment outcomes and survival rates.
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