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Ch. 2 - Transmission Genetics
Sanders - Genetic Analysis: An Integrated Approach 3rd Edition
Sanders3rd EditionGenetic Analysis: An Integrated ApproachISBN: 9780135564172Not the one you use?Change textbook
Chapter 2, Problem 10a

The dorsal pigment pattern of frogs can be either 'leopard' (white pigment between dark spots) or 'mottled' (pigment between spots appears mottled). The trait is controlled by an autosomal gene. Males and females are selected from pure-breeding populations, and a pair of reciprocal crosses is performed. The cross results are shown below.
    Cross 1:  P₁: Male leopard x male mottled
             F₁: All mottled
             F₂: 70 mottled, 22 leopard
    Cross 2:  P₁: Male mottled x female leopard
             F₁: All mottled
             F₂: 50 mottled, 18 leopard
Which of the phenotypes is dominant? Explain your answer.

Verified step by step guidance
1
Step 1: Understand the problem. The dorsal pigment pattern in frogs is controlled by an autosomal gene, and the phenotypes are 'leopard' and 'mottled'. The goal is to determine which phenotype is dominant based on the results of reciprocal crosses.
Step 2: Analyze the F₁ generation results. In both crosses, the F₁ generation consists entirely of mottled frogs, regardless of the parental phenotypes. This suggests that the mottled phenotype is dominant, as it appears in all offspring when crossed with leopard frogs.
Step 3: Examine the F₂ generation results. In Cross 1, the F₂ generation shows a ratio of 70 mottled to 22 leopard frogs. In Cross 2, the F₂ generation shows a ratio of 50 mottled to 18 leopard frogs. These ratios are consistent with a Mendelian inheritance pattern for a single autosomal gene with dominant and recessive alleles.
Step 4: Apply Mendelian genetics principles. If mottled is dominant and leopard is recessive, the F₁ generation (heterozygous) would produce a 3:1 phenotypic ratio in the F₂ generation (3 mottled:1 leopard). The observed ratios in both crosses approximate this expected ratio, further supporting the conclusion that mottled is dominant.
Step 5: Conclude based on evidence. The dominance of the mottled phenotype is supported by its appearance in all F₁ offspring and the approximate 3:1 ratio in the F₂ generation. This aligns with the principles of autosomal inheritance for a dominant-recessive trait.

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Key Concepts

Here are the essential concepts you must grasp in order to answer the question correctly.

Dominance in Genetics

Dominance refers to the relationship between alleles of a gene, where one allele masks the expression of another in the phenotype. In this case, if all F₁ offspring from both crosses exhibit the mottled phenotype, it suggests that the allele for mottled is dominant over the allele for leopard.
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Variations on Dominance

Phenotypic Ratios

Phenotypic ratios are the relative frequencies of different phenotypes in the offspring resulting from a genetic cross. The F₂ generation shows a consistent ratio of mottled to leopard phenotypes, which can be analyzed to determine the dominance of traits. The observed ratios help confirm the dominance of the mottled phenotype.
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Mutations and Phenotypes

Reciprocal Crosses

Reciprocal crosses involve switching the sexes of the parents in a genetic cross to determine if the inheritance pattern is influenced by sex. In this scenario, both crosses yield the same F₁ and F₂ results, indicating that the dominance of the mottled phenotype is not sex-linked, reinforcing the conclusion about the trait's inheritance.
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Related Practice
Textbook Question

Determine whether the statements below are true or false. If a statement is false, provide the correct information or revise the statement to make it correct.

If a dihybrid plant is self-fertilized,

(1) 9/16 of the progeny will have the same phenotype as the F₁ parent.

(2) 1/16 of the progeny will be true-breeding.

(3) 1/2 of the progeny will be heterozygous at one or both loci.

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Textbook Question

In the datura plant, purple flower color is controlled by a dominant allele, P. White flowers are found in plants homozygous for the recessive allele p. Suppose that a purple-flowered datura plant with an unknown genotype is self-fertilized and that its progeny are 28 purple-flowered plants and 10 white-flowered plants.

Use the results of the self-fertilization to determine the genotype of the original purple-flowered plant.

426
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Textbook Question

In the datura plant, purple flower color is controlled by a dominant allele, P. White flowers are found in plants homozygous for the recessive allele p. Suppose that a purple-flowered datura plant with an unknown genotype is self-fertilized and that its progeny are 28 purple-flowered plants and 10 white-flowered plants.

If one of the purple-flowered progeny plants is selected at random and self-fertilized, what is the probability it will breed true?

693
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Textbook Question

The dorsal pigment pattern of frogs can be either 'leopard' (white pigment between dark spots) or 'mottled' (pigment between spots appears mottled). The trait is controlled by an autosomal gene. Males and females are selected from pure-breeding populations, and a pair of reciprocal crosses is performed. The cross results are shown below.

    Cross 1:  P₁: Male leopard x male mottled

             F₁: All mottled

             F₂: 70 mottled, 22 leopard

    Cross 2:  P₁: Male mottled x female leopard

             F₁: All mottled

             F₂: 50 mottled, 18 leopard

Compare and contrast the results of the reciprocal crosses in the context of autosomal gene inheritance.

509
views
Textbook Question

The dorsal pigment pattern of frogs can be either 'leopard' (white pigment between dark spots) or 'mottled' (pigment between spots appears mottled). The trait is controlled by an autosomal gene. Males and females are selected from pure-breeding populations, and a pair of reciprocal crosses is performed. The cross results are shown below.

    Cross 1:  P₁: Male leopard x male mottled

             F₁: All mottled

             F₂: 70 mottled, 22 leopard

    Cross 2:  P₁: Male mottled x female leopard

             F₁: All mottled

             F₂: 50 mottled, 18 leopard

In the F₂ progeny from both crosses, what proportion is expected to be homozygous? What proportion is expected to be heterozygous?

499
views
Textbook Question

The dorsal pigment pattern of frogs can be either 'leopard' (white pigment between dark spots) or 'mottled' (pigment between spots appears mottled). The trait is controlled by an autosomal gene. Males and females are selected from pure-breeding populations, and a pair of reciprocal crosses is performed. The cross results are shown below.

    Cross 1:  P₁: Male leopard x male mottled

             F₁: All mottled

             F₂: 70 mottled, 22 leopard

    Cross 2:  P₁: Male mottled x female leopard

             F₁: All mottled

             F₂: 50 mottled, 18 leopard

Propose two different genetic crosses that would allow you to determine the genotype of one mottled frog from the F₂ generation.

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