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Ch. 20 - Population Genetics and Evolution at the Population, Species, and Molecular Levels
Sanders - Genetic Analysis: An Integrated Approach 3rd Edition
Sanders3rd EditionGenetic Analysis: An Integrated ApproachISBN: 9780135564172Not the one you use?Change textbook
Chapter 20, Problem 18

In a population of rabbits, f(C₁) = 0.70 and f(C₂) = 0.30. The alleles exhibit an incomplete dominance relationship in which C₁C₁ produces black rabbits, C₁C₂ produces tan-colored rabbits, and C₂C₂ produces rabbits with white fur. If the assumptions of the Hardy–Weinberg principle apply to the rabbit population, what are the expected frequencies of black, tan, and white rabbits?

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Step 1: Recall the Hardy-Weinberg principle, which states that allele and genotype frequencies in a population will remain constant from generation to generation in the absence of evolutionary influences. The equation for genotype frequencies is p² + 2pq + q² = 1, where p and q are the frequencies of two alleles in the population.
Step 2: Identify the allele frequencies given in the problem. Here, f(C₁) = 0.70 (p) and f(C₂) = 0.30 (q). These represent the frequencies of the two alleles in the population.
Step 3: Calculate the expected frequency of the homozygous genotype C₁C₁ (black rabbits) using the formula p². This is done by squaring the frequency of the C₁ allele: p² = (0.70)².
Step 4: Calculate the expected frequency of the heterozygous genotype C₁C₂ (tan-colored rabbits) using the formula 2pq. This is done by multiplying 2 by the frequency of C₁ (p) and the frequency of C₂ (q): 2pq = 2 × 0.70 × 0.30.
Step 5: Calculate the expected frequency of the homozygous genotype C₂C₂ (white rabbits) using the formula q². This is done by squaring the frequency of the C₂ allele: q² = (0.30)².

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Key Concepts

Here are the essential concepts you must grasp in order to answer the question correctly.

Hardy-Weinberg Principle

The Hardy-Weinberg principle provides a mathematical model for understanding genetic variation in a population at equilibrium. It states that allele and genotype frequencies will remain constant from generation to generation in the absence of evolutionary influences. This principle assumes no mutation, migration, selection, or genetic drift, allowing for the prediction of expected genotype frequencies based on allele frequencies.
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Incomplete Dominance

Incomplete dominance is a genetic scenario where neither allele is completely dominant over the other, resulting in a phenotype that is a blend of both. In the case of the rabbit population, the heterozygous genotype (C₁C₂) produces a distinct tan color, while homozygous genotypes produce black (C₁C₁) and white (C₂C₂) rabbits. This concept is crucial for understanding how different allele combinations affect phenotypic expression.
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Genotype Frequencies

Genotype frequencies refer to the proportion of different genotypes within a population. In the context of the Hardy-Weinberg principle, these frequencies can be calculated using the allele frequencies. For the rabbit population, the expected frequencies of black, tan, and white rabbits can be derived from the allele frequencies (f(C₁) and f(C₂)) and the genotypic ratios that result from incomplete dominance.
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Related Practice
Textbook Question
What is inbreeding depression? Why is inbreeding depression a serious concern for animal biologists involved in species-conservation breeding programs?
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Textbook Question

Certain animal species, such as the black-footed ferret, are nearly extinct and currently exist only in captive populations. Other species, such as the panda, are also threatened but exist in the wild thanks to intensive captive breeding programs. What strategies would you suggest in the case of black-footed ferrets and in the case of pandas to monitor and minimize inbreeding depression?

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Textbook Question

Genetic Analysis 20.1 predicts the number of individuals expected to have the blood group genotypes MM, MN, and NN. Perform a chi-square analysis using the number of people observed and expected in each blood-type category, and state whether the sample is in H-W equilibrium.

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Textbook Question

Sickle cell disease (SCD) is found in numerous populations whose ancestral homes are in the malaria belt of Africa and Asia. SCD is an autosomal recessive disorder that results from homozygosity for a mutant β-globin gene allele. Data on one affected population indicates that approximately 8 in 100 newborn infants have SCD.

What are the frequencies of the wild-type (βᴬ) and mutant (βˢ) alleles in this population?

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Textbook Question

Sickle cell disease (SCD) is found in numerous populations whose ancestral homes are in the malaria belt of Africa and Asia. SCD is an autosomal recessive disorder that results from homozygosity for a mutant β-globin gene allele. Data on one affected population indicates that approximately 8 in 100 newborn infants have SCD.

What is the frequency of carriers of SCD in the population?

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Textbook Question

Epidemiologic data on the population in the previous problem reveal that before the application of modern medical treatment, natural selection played a major role in shaping the frequencies of alleles. Heterozygous individuals have the highest relative fitness, and in comparison with heterozygotes, those who are βᴬβᴬ have a relative fitness of 82%, but only about 32% of those with SCD survived to reproduce. What are the estimated equilibrium frequencies of βᴬ and βˢ in this population?

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