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04:24Lesch–Nyhan syndrome (OMIM 300322) is a rare X-linked recessive disorder that produces severe mental retardation, spastic cerebral palsy, and self-mutilation.
What is the probability that the first son of a woman whose brother has Lesch–Nyhan syndrome will be affected?
Lesch–Nyhan syndrome (OMIM 300322) is a rare X-linked recessive disorder that produces severe mental retardation, spastic cerebral palsy, and self-mutilation.
If the first son of the woman described in (a) is affected, what is the probability that her second son is affected?
Lesch–Nyhan syndrome (OMIM 300322) is a rare X-linked recessive disorder that produces severe mental retardation, spastic cerebral palsy, and self-mutilation.
What is the probability that the first son of a man whose brother has Lesch–Nyhan syndrome will be affected?
In an 1889 book titled Natural Inheritance (Macmillan, New York), Francis Galton, who investigated the inheritance of measurable (quantitative) traits, formulated a law of 'ancestral inheritance.' The law stated that individuals inherit approximately one-half of their genetic traits from each parent, about one-quarter of the traits from each grandparent, one-eighth from each great grandparent, and so on. In light of the chromosome theory of heredity, argue either in favor of Galton's law or against it.
In Drosophila, the X-linked echinus eye phenotype disrupts formation of facets and is recessive to wild-type eye. Autosomal recessive traits vestigial wing and ebony body assort independently of one another. Examine the progeny from the three crosses shown below, and identify the genotype of parents in each cross.
A wild-type Drosophila male and female are crossed, producing 324 female progeny and 161 male progeny. All their progeny are wild type.
Propose a genetic hypothesis to explain these data.
