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Ch. 4 - Gene Interaction
Sanders - Genetic Analysis: An Integrated Approach 3rd Edition
Sanders3rd EditionGenetic Analysis: An Integrated ApproachISBN: 9780135564172Not the one you use?Change textbook
Chapter 4, Problem 19a

Feather color in parakeets is produced by the blending of pigments from two biosynthetic pathways shown below. Four independently assorting genes (A, B, C, and D) produce enzymes that catalyze separate steps of the pathways. For the questions below, use an uppercase letter to indicate a dominant allele producing full enzymatic activity and a lowercase letter to indicate a recessive allele producing no functional enzyme. Feather colors produced by mixing pigments are green (yellow + blue) and purple (red + blue). Red, yellow, and blue feathers result from the production of one colored pigment, and white results from the absence of pigment production.
Diagram of two biosynthetic pathways for parakeet feather color production.
What is the genotype of a pure-breeding purple parakeet strain? 

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1
Analyze the biosynthetic pathways provided in the diagram. Pathway I produces red and yellow pigments, while Pathway II produces blue pigment. The blending of pigments determines feather color.
For a parakeet to have purple feathers, it must produce both red and blue pigments. This means that Pathway I must be functional up to Compound II (red pigment), and Pathway II must be functional up to Compound Z (blue pigment).
Identify the genes involved: Gene A encodes Enzyme A (required for red pigment production in Pathway I), Gene B encodes Enzyme B (required for yellow pigment in Pathway I and blue pigment in Pathway II), and Gene C encodes Enzyme C (required for blue pigment production in Pathway II).
To ensure a pure-breeding purple parakeet strain, all alleles responsible for pigment production must be homozygous dominant. This ensures full enzymatic activity in both pathways. The genotype would be AABBCC, where each uppercase letter represents a dominant allele producing functional enzymes.
Verify the genotype: AABBCC ensures that Enzyme A, Enzyme B, and Enzyme C are all functional, leading to the production of red and blue pigments. The combination of these pigments results in purple feathers.

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Key Concepts

Here are the essential concepts you must grasp in order to answer the question correctly.

Genotype and Phenotype

The genotype refers to the genetic makeup of an organism, specifically the alleles present for a given trait. In contrast, the phenotype is the observable expression of that genotype, influenced by both genetic and environmental factors. For example, a parakeet's feather color is a phenotype resulting from its genotype, which determines the production of pigments through enzymatic pathways.
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Dominant and Recessive Alleles

In genetics, alleles can be classified as dominant or recessive based on their effects on phenotype. A dominant allele, represented by an uppercase letter, can mask the presence of a recessive allele, denoted by a lowercase letter. In the context of parakeet feather color, the presence of at least one dominant allele for the relevant genes will result in the production of specific pigments, while recessive alleles lead to a lack of pigment.
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Biosynthetic Pathways

Biosynthetic pathways are series of chemical reactions in a cell that lead to the production of complex molecules from simpler ones. In the case of parakeet feather color, two distinct pathways produce different pigments through the action of specific enzymes. Understanding these pathways is crucial for determining how various genotypes result in the observed feather colors, such as purple, which arises from the combination of red and blue pigments.
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Related Practice
Textbook Question

Strains of petunias come in four pure-breeding colors: white, blue, red, and purple. White petunias are produced when plants synthesize no flower pigment. Blue petunias and red petunias are produced when plants synthesize blue or red pigment only. Purple petunias are produced in plants that synthesize both red and blue pigment (the mixture of red and blue makes purple). Flower-color pigments are synthesized by gene action in two separate pigment-producing biochemical pathways. Pathway I contains gene A that produces an enzyme to catalyze conversion of a colorless pigment designated to blue pigment. In Pathway II, the enzymatic product of gene B converts the colorless pigment designated to red pigment. The two genes assort independently.

What are the possible genotype(s) for pure-breeding red petunias? 

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Textbook Question

Strains of petunias come in four pure-breeding colors: white, blue, red, and purple. White petunias are produced when plants synthesize no flower pigment. Blue petunias and red petunias are produced when plants synthesize blue or red pigment only. Purple petunias are produced in plants that synthesize both red and blue pigment (the mixture of red and blue makes purple). Flower-color pigments are synthesized by gene action in two separate pigment-producing biochemical pathways. Pathway I contains gene A that produces an enzyme to catalyze conversion of a colorless pigment designated to blue pigment. In Pathway II, the enzymatic product of gene B converts the colorless pigment designated to red pigment. The two genes assort independently.

What are the possible genotype(s) for true-breeding blue petunias? 

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Textbook Question

Strains of petunias come in four pure-breeding colors: white, blue, red, and purple. White petunias are produced when plants synthesize no flower pigment. Blue petunias and red petunias are produced when plants synthesize blue or red pigment only. Purple petunias are produced in plants that synthesize both red and blue pigment (the mixture of red and blue makes purple). Flower-color pigments are synthesized by gene action in two separate pigment-producing biochemical pathways. Pathway I contains gene A that produces an enzyme to catalyze conversion of a colorless pigment designated to blue pigment. In Pathway II, the enzymatic product of gene B converts the colorless pigment designated to red pigment. The two genes assort independently.

True-breeding red petunias are crossed to pure-breeding blue petunias, and all the F₁ progeny have purple flowers. If the F₁ are allowed to self-fertilize and produce the F₂, what is the expected phenotypic distribution of the F₂ progeny? Show your work.

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Textbook Question

Feather color in parakeets is produced by the blending of pigments from two biosynthetic pathways shown below. Four independently assorting genes (A, B, C, and D) produce enzymes that catalyze separate steps of the pathways. For the questions below, use an uppercase letter to indicate a dominant allele producing full enzymatic activity and a lowercase letter to indicate a recessive allele producing no functional enzyme. Feather colors produced by mixing pigments are green (yellow + blue) and purple (red + blue). Red, yellow, and blue feathers result from the production of one colored pigment, and white results from the absence of pigment production.

What is the genotype of a pure-breeding yellow strain of parakeet? 

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Textbook Question

Feather color in parakeets is produced by the blending of pigments from two biosynthetic pathways shown below. Four independently assorting genes (A, B, C, and D) produce enzymes that catalyze separate steps of the pathways. For the questions below, use an uppercase letter to indicate a dominant allele producing full enzymatic activity and a lowercase letter to indicate a recessive allele producing no functional enzyme. Feather colors produced by mixing pigments are green (yellow + blue) and purple (red + blue). Red, yellow, and blue feathers result from production of one colored pigment, and white results from absence of pigment production.

If F₁ birds identified in part (c) are mated at random, what phenotypes do you expect in the F₂ generation? What are the ratios among phenotypes? Show your work. 

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