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Ch. 4 - Gene Interaction
Sanders - Genetic Analysis: An Integrated Approach 3rd Edition
Sanders3rd EditionGenetic Analysis: An Integrated ApproachISBN: 9780135564172Not the one you use?Change textbook
Chapter 4, Problem 19b

Feather color in parakeets is produced by the blending of pigments from two biosynthetic pathways shown below. Four independently assorting genes (A, B, C, and D) produce enzymes that catalyze separate steps of the pathways. For the questions below, use an uppercase letter to indicate a dominant allele producing full enzymatic activity and a lowercase letter to indicate a recessive allele producing no functional enzyme. Feather colors produced by mixing pigments are green (yellow + blue) and purple (red + blue). Red, yellow, and blue feathers result from the production of one colored pigment, and white results from the absence of pigment production.
Diagram showing two biosynthetic pathways for parakeet feather color production.
What is the genotype of a pure-breeding yellow strain of parakeet? 

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1
Analyze the biosynthetic pathways provided in the diagram. Pathway I involves the conversion of a colorless compound to red (Compound II) by Enzyme A, and then to yellow (Compound III) by Enzyme B. Pathway II involves the conversion of a colorless compound to blue (Compound Z) by Enzyme C and Enzyme B.
Understand that a pure-breeding yellow strain of parakeet must produce only yellow pigment. This means that Pathway I must be functional up to Compound III, while Pathway II must be non-functional to prevent the production of blue pigment.
Determine the genotype for Pathway I. For yellow pigment to be produced, Enzyme A and Enzyme B must be functional. This requires at least one dominant allele for both genes A and B, so the genotype for these genes must include at least one uppercase A and one uppercase B (e.g., A_B_).
Determine the genotype for Pathway II. To prevent the production of blue pigment, Enzyme C must be non-functional. This requires two recessive alleles for gene C (cc). Additionally, Enzyme B in Pathway II does not need to be considered separately, as it is already functional in Pathway I.
Combine the information from both pathways. The genotype of a pure-breeding yellow strain must include functional alleles for genes A and B (e.g., A_B_) and non-functional alleles for gene C (cc). Since the strain is pure-breeding, the genotype must be homozygous for all genes, resulting in AABBcc.

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Key Concepts

Here are the essential concepts you must grasp in order to answer the question correctly.

Genotype and Phenotype

The genotype refers to the genetic makeup of an organism, specifically the alleles present for a given trait. In contrast, the phenotype is the observable expression of that genotype, influenced by both genetic and environmental factors. For example, in parakeets, a pure-breeding yellow strain would have a specific genotype that results in the production of yellow feathers, demonstrating the relationship between genotype and phenotype.
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Dominant and Recessive Alleles

In genetics, alleles can be classified as dominant or recessive based on their effects on phenotype. A dominant allele, represented by an uppercase letter, can mask the effect of a recessive allele, denoted by a lowercase letter. In the context of parakeet feather color, the presence of dominant alleles for enzymes involved in pigment production will lead to the expression of specific colors, such as yellow, while recessive alleles may result in a lack of pigment.
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Biosynthetic Pathways

Biosynthetic pathways are series of chemical reactions in a cell that lead to the production of complex molecules from simpler ones. In the case of parakeet feather color, two distinct pathways produce different pigments through enzymatic reactions. Understanding these pathways is crucial for determining how specific genotypes lead to the production of colors like yellow and blue, as well as how these colors can blend to create other phenotypes.
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Related Practice
Textbook Question

Strains of petunias come in four pure-breeding colors: white, blue, red, and purple. White petunias are produced when plants synthesize no flower pigment. Blue petunias and red petunias are produced when plants synthesize blue or red pigment only. Purple petunias are produced in plants that synthesize both red and blue pigment (the mixture of red and blue makes purple). Flower-color pigments are synthesized by gene action in two separate pigment-producing biochemical pathways. Pathway I contains gene A that produces an enzyme to catalyze conversion of a colorless pigment designated to blue pigment. In Pathway II, the enzymatic product of gene B converts the colorless pigment designated to red pigment. The two genes assort independently.

What are the possible genotype(s) for true-breeding blue petunias? 

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Textbook Question

Strains of petunias come in four pure-breeding colors: white, blue, red, and purple. White petunias are produced when plants synthesize no flower pigment. Blue petunias and red petunias are produced when plants synthesize blue or red pigment only. Purple petunias are produced in plants that synthesize both red and blue pigment (the mixture of red and blue makes purple). Flower-color pigments are synthesized by gene action in two separate pigment-producing biochemical pathways. Pathway I contains gene A that produces an enzyme to catalyze conversion of a colorless pigment designated to blue pigment. In Pathway II, the enzymatic product of gene B converts the colorless pigment designated to red pigment. The two genes assort independently.

True-breeding red petunias are crossed to pure-breeding blue petunias, and all the F₁ progeny have purple flowers. If the F₁ are allowed to self-fertilize and produce the F₂, what is the expected phenotypic distribution of the F₂ progeny? Show your work.

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Textbook Question

Feather color in parakeets is produced by the blending of pigments from two biosynthetic pathways shown below. Four independently assorting genes (A, B, C, and D) produce enzymes that catalyze separate steps of the pathways. For the questions below, use an uppercase letter to indicate a dominant allele producing full enzymatic activity and a lowercase letter to indicate a recessive allele producing no functional enzyme. Feather colors produced by mixing pigments are green (yellow + blue) and purple (red + blue). Red, yellow, and blue feathers result from the production of one colored pigment, and white results from the absence of pigment production.

What is the genotype of a pure-breeding purple parakeet strain? 

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Textbook Question

Feather color in parakeets is produced by the blending of pigments from two biosynthetic pathways shown below. Four independently assorting genes (A, B, C, and D) produce enzymes that catalyze separate steps of the pathways. For the questions below, use an uppercase letter to indicate a dominant allele producing full enzymatic activity and a lowercase letter to indicate a recessive allele producing no functional enzyme. Feather colors produced by mixing pigments are green (yellow + blue) and purple (red + blue). Red, yellow, and blue feathers result from production of one colored pigment, and white results from absence of pigment production.

If F₁ birds identified in part (c) are mated at random, what phenotypes do you expect in the F₂ generation? What are the ratios among phenotypes? Show your work. 

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Textbook Question

Brachydactyly type D is a human autosomal dominant condition in which the thumbs are abnormally short and broad. In most cases, both thumbs are affected, but occasionally just one thumb is involved. The accompanying pedigree shows a family in which brachydactyly type D is segregating. Filled circles and squares represent females and males who have involvement of both thumbs. Half-filled symbols represent family members with just one thumb affected.

Is there any evidence of variable expressivity in this family? Explain. 

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