17. Mutation, Repair, and Recombination
DNA Repair
17. Mutation, Repair, and Recombination
DNA Repair
1
concept
DNA Proofreading
1m
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2
concept
Repair Pathways
5m
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3
concept
Translesion Synthesis
2m
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4
concept
Double Strand Breaks
3m
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5
Problem
ProblemWhich of the following repair pathways repairs damage that causes distortions in the double helix?
A
Base Excision Repair
B
Nucleotide Excision Repair
C
Mismatch Repair
D
Homologous Recombination
6
Problem
ProblemWhich of the following repair pathways uses a methylated strand of DNA to correct DNA damage?
A
Base Excision Repair
B
Nucleotide Excision Repair
C
Mismatch Repair
D
Homologous Recombination
7
Problem
ProblemTrue or False:Translesion DNA synthesis is the first mechanism the cell uses to repair DNA damage?
A
True
B
False
8
Problem
ProblemWhich of the following pathways is an error-free way to repair double-stranded breaks?
A
Homologous recombination
B
Non-homologous end joining
C
Translesion synthesis
D
Mismatch repair
Additional resources for DNA Repair
PRACTICE PROBLEMS AND ACTIVITIES (30)
- Write a short essay contrasting how these concepts may differ between bacteria and eukaryotes.
- Answer the following questions concerning the accuracy of DNA polymerase during replication.Identify two mecha...
- Answer the following questions concerning the accuracy of DNA polymerase during replication.If a DNA replicati...
- Answer the following questions concerning the accuracy of DNA polymerase during replication.DNA mismatch repai...
- Answer the following questions concerning the accuracy of DNA polymerase during replication.If the kind of abn...
- Answer the following questions concerning the accuracy of DNA polymerase during replication.If a replication e...
- Answer the following questions concerning the accuracy of DNA polymerase during replication.What general mecha...
- DNA damage brought on by a variety of natural and artificial agents elicits a wide variety of cellular respons...
- Contrast the various types of DNA repair mechanisms known to counteract the effects of UV radiation. What is t...
- A 1-mL sample of the bacterium E. coli is exposed to ultraviolet light. The sample is used to inoculate a 500-...
- A strain of E. coli is identified as having a null mutation of the RecA gene. What biological property do you ...
- It has been shown that infectious agents such as viruses often exert a dramatic effect on their host cell's ge...
- Xeroderma pigmentosum (XP) is an autosomal recessive condition characterized by moderate to severe sensitivity...
- You have identified five genes in S. cerevisiae that are induced when the yeast are grown in a high-salt (NaCl...
- You have identified five genes in S. cerevisiae that are induced when the yeast are grown in a high-salt (NaCl...
- The SOS repair genes in E. coli (discussed in Chapter 15) are negatively regulated by the lexA gene product, c...
- Describe the 'end-replication problem' in eukaryotes. How is it resolved?
- A fellow student considers the issues in Problem 22 and argues that there is a more straightforward, nongeneti...
- Many of the gene products involved in DNA synthesis were initially defined by studying mutant E. coli strains ...
- Many of the gene products involved in DNA synthesis were initially defined by studying mutant E. coli strains ...
- When a double-strand DNA break occurs in a eukaryotic cell, it may be repaired by either nonhomologous end joi...
- Using your knowledge of DNA repair pathways, choose the pathway that would be used to repair the following typ...
- Using your knowledge of DNA repair pathways, choose the pathway that would be used to repair the following typ...
- Ataxia telangiectasia (OMIM 208900) is a human inherited disorder characterized by poor coordination (ataxia),...
- A geneticist searching for mutations uses the restriction endonucleases SmaI and PvuII to search for mutations...
- A geneticist searching for mutations uses the restriction endonucleases SmaI and PvuII to search for mutations...
- A geneticist searching for mutations uses the restriction endonucleases SmaI and PvuII to search for mutations...
- In a mouse-breeding experiment a new mutation called Dumbo is identified. A mouse with the Dumbo mutation has ...
- Considering the Dumbo mutation in Problem 37, what kinds of additional evidence would help you determine wheth...
- Thinking back to the discussion of gain-of-function and loss-of-function mutations in Section 4.1, and putting...