What type of interactions between an enzyme and its substrate help to stabilize ES?

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Hello, everyone. Let's look at our next question. It says what type of interaction will most likely stabilize an enzyme substrate or es complex involving a substrate with a large non polar region. A ionic bonding B hydrogen bonding C hydrophobic interactions or D covalent bonding. So in a case where we have a large nonpolar region, the interactions you'd most likely expect would be choice c hydrophobic interactions since the nonpolar substrate and then the hydrophobic, in this case, active site would be looking to stay away from the aqueous environment. When we look at our other answer choices, uh choice, a ionic bonding of course would involve charged molecules which would not be our large nonpolar substrate. So that's not going to be our answer. Choice. B hydrogen bonding of course, takes place when you have polar molecules that contain hydrogen atoms. So you have a pretty large disparity of electron electron. And we instead have a nonpolar region. And then choice d covalent bonding those bonds where you have the sharing of electrons between atoms but covalent bonds are quite strong and stable arrangements. So that would be unlikely in a transient enzyme substrate interaction. You want your substrate to come in into the active site. The reaction is catalyzed and then the product goes out. So you wouldn't want this stable covalent bond forming. So that's going to be not an unlikely answer. So once again, the type of interaction that would most likely stabilize an enzyme substrate complex. When the substrate has a large non polar region is choice c hydrophobic interactions. See you in the next video.

What type of interactions between an enzyme and its substrate help to stabilize ES?

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Key Concepts

Enzyme-Substrate Complex

Binding Interactions

Induced Fit Model