Textbook Question
How many molecules of acetyl-CoA result from complete catabolism of the following compounds?
a. Myristic acid, CH3(CH2)12COOH
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Ch.24 Lipid Metabolism
McMurry8th EditionFundamentals of GOBISBN: 9780134015187
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Table of contents
- Ch.1 Matter and Measurements27
- Ch.2 Atoms and the Periodic Table20
- Ch.3 Ionic Compounds8
- Ch.4 Molecular Compounds23
- Ch.5 Classification & Balancing of Chemical Reactions12
- Ch.6 Chemical Reactions: Mole and Mass Relationships28
- Ch.7 Chemical Reactions: Energy, Rate and Equilibrium64
- Ch.8 Gases, Liquids and Solids24
- Ch.9 Solutions52
- Ch.10 Acids and Bases25
- Ch.11 Nuclear Chemistry22
- Ch.12 Introduction to Organic Chemistry: Alkanes57
- Ch.13 Alkenes, Alkynes, and Aromatic Compounds47
- Ch.14 Some Compounds with Oxygen, Sulfur, or a Halogen50
- Ch.15 Aldehydes and Ketones45
- Ch.16 Amines42
- Ch.17 Carboxylic Acids and Their Derivatives57
- Ch.18 Amino Acids and Proteins82
- Ch.19 Enzymes and Vitamins63
- Ch.20 Carbohydrates44
- Ch.21 The Generation of Biochemical Energy65
- Ch.22 Carbohydrate Metabolism45
- Ch.23 Lipids42
- Ch.24 Lipid Metabolism33
- Ch.25 Protein and Amino Acid Metabolism24
- Ch.26 Nucleic Acids and Protein Synthesis45
Chapter 24, Problem 60
How many rounds of the lipogenesis cycle are needed to synthesize stearic acid, C17H35COOH?
Verified step by step guidance1
Understand the problem: Lipogenesis is the process by which fatty acids are synthesized. Each round of the lipogenesis cycle adds a two-carbon unit to the growing fatty acid chain. Stearic acid (C17H35COOH) is a saturated fatty acid with 18 carbon atoms in total.
Determine the starting molecule: The lipogenesis cycle begins with acetyl-CoA, which contributes two carbons in the first step. Malonyl-CoA is then used in subsequent cycles to add two-carbon units.
Calculate the total number of carbons in stearic acid: Stearic acid has 18 carbons (17 from the hydrocarbon chain and 1 from the carboxylic acid group).
Account for the first two carbons: The first two carbons are provided by acetyl-CoA in the initial step of the cycle. This leaves 16 carbons to be added through subsequent rounds of the cycle.
Divide the remaining carbons by 2: Since each round of the lipogenesis cycle adds two carbons, divide the remaining 16 carbons by 2 to determine the number of additional rounds required. Add 1 for the initial step to get the total number of rounds.
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Key Concepts
Here are the essential concepts you must grasp in order to answer the question correctly.
Lipogenesis
Lipogenesis is the metabolic process through which fatty acids are synthesized from acetyl-CoA and other substrates. This process primarily occurs in the liver and adipose tissue and involves a series of enzymatic reactions that convert excess carbohydrates into fatty acids, which can then be stored as triglycerides.
Fatty Acid Synthesis
Fatty acid synthesis involves multiple cycles of the lipogenesis pathway, where each cycle elongates the fatty acid chain by two carbon atoms. The process begins with acetyl-CoA and requires NADPH as a reducing agent, with the final product being a saturated fatty acid, such as stearic acid, which has 18 carbon atoms.
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Stearic Acid
Stearic acid is a long-chain saturated fatty acid with the chemical formula C18H36O2. It is produced through the lipogenesis cycle and is important for various biological functions, including energy storage and membrane structure. To synthesize stearic acid, multiple rounds of the lipogenesis cycle are required, specifically 9 cycles, as each cycle adds two carbon atoms to the growing fatty acid chain.
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Related Practice
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What causes acetone to be present in the breath of someone with uncontrolled diabetes?
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Textbook Question
Name the starting material for fatty acid synthesis.
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Textbook Question
Consuming too many carbohydrates causes deposition of fats in adipose tissue. How does this happen?
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Textbook Question
Why are extra calories consumed as carbohydrates stored as fat and not as glycogen?
1021
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Textbook Question
Lipoproteins that transport lipids from the diet are described as exogenous. Those that transport lipids produced in metabolic pathways are described as endogenous. Which of the following lipoproteins transports exogenous lipids and which transports endogenous lipids?
a. Low-density lipoprotein (LDL)
b. Chylomicrons
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