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Ch.11 Nucleic Acids Big Molecules with a Big Role
Frost - General, Organic and Biological Chemistry 4th Edition
Frost4th EditionGeneral, Organic and Biological ChemistryISBN: 9780134988696Not the one you use?Change textbook
Chapter 7, Problem 59

How do the bases thymine and uracil differ?

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Thymine and uracil are both pyrimidine bases found in nucleic acids.
Thymine is found in DNA, while uracil is found in RNA.
Thymine has a methyl group at the 5th carbon position, which uracil lacks.
Uracil is structurally similar to thymine but without the methyl group, making it less stable.
The presence of thymine in DNA helps protect the genetic material from mutations, while uracil in RNA allows for more flexibility in function.

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Key Concepts

Here are the essential concepts you must grasp in order to answer the question correctly.

Nucleotide Structure

Nucleotides are the building blocks of nucleic acids like DNA and RNA. Each nucleotide consists of a sugar, a phosphate group, and a nitrogenous base. Thymine and uracil are both nitrogenous bases, but they differ in their chemical structure, which influences their roles in DNA and RNA.
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Base Pairing

Base pairing is a fundamental concept in molecular biology that describes how nitrogenous bases pair with each other to form the structure of DNA and RNA. In DNA, thymine pairs with adenine, while in RNA, uracil replaces thymine and pairs with adenine. This difference is crucial for understanding the stability and function of genetic material.
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Function in Genetic Material

Thymine and uracil serve different functions in genetic material. Thymine is found exclusively in DNA, contributing to its stability and integrity, while uracil is present in RNA, where it plays a role in protein synthesis and gene expression. Understanding these functions helps clarify the distinct roles of DNA and RNA in biological systems.
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