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Ch. 1 - The Molecular Basis of Heredity, Variation, and Evolution
Sanders - Genetic Analysis: An Integrated Approach 3rd Edition
Sanders3rd EditionGenetic Analysis: An Integrated ApproachISBN: 9780135564172Not the one you use?Change textbook
Chapter 1, Problem 30d

Ethical and social issues have become a large part of the public discussion of genetics and genetic testing. Choose two of the propositions presented here and prepare a list of arguments for and against them.


Gene therapy should be used on humans when it can correct a hereditary condition such as sickle cell disease.

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1
Understand the proposition: The statement suggests using gene therapy to correct hereditary conditions like sickle cell disease. Gene therapy involves altering or replacing defective genes to treat or prevent diseases.
Identify arguments in favor of the proposition: Consider the potential benefits, such as improving the quality of life for individuals with hereditary conditions, reducing healthcare costs associated with managing chronic diseases, and advancing medical science.
Identify arguments against the proposition: Reflect on potential risks, such as unforeseen side effects, ethical concerns about altering human genetics, and the possibility of unequal access to such treatments, which could exacerbate social inequalities.
Organize the arguments: Create a clear list of 'pros' and 'cons' for the use of gene therapy in this context. For example, under 'pros,' include points like 'eliminates the root cause of the disease,' and under 'cons,' include points like 'long-term effects are unknown.'
Evaluate the ethical and social implications: Consider broader questions, such as whether gene therapy should be limited to life-threatening conditions, how to ensure equitable access, and how society might regulate its use to prevent misuse or unintended consequences.

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Key Concepts

Here are the essential concepts you must grasp in order to answer the question correctly.

Gene Therapy

Gene therapy is a medical technique that involves altering the genes inside a person's cells to treat or prevent disease. It aims to correct genetic disorders by introducing, removing, or altering genetic material within a patient's cells. This approach has the potential to address hereditary conditions like sickle cell disease, but it raises ethical questions about its implications and long-term effects.
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Ethical Considerations

Ethical considerations in genetics involve the moral implications of genetic testing and interventions, such as gene therapy. Key issues include the potential for unintended consequences, the fairness of access to such treatments, and the implications of 'playing God' by altering human genetics. These considerations are crucial in guiding policies and practices in genetic medicine.
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Informed Consent

Informed consent is a fundamental principle in medical ethics that requires patients to be fully informed about the risks, benefits, and alternatives of a treatment before agreeing to it. In the context of gene therapy, it is essential that patients understand the experimental nature of the treatment, potential side effects, and the implications for future generations, ensuring that their decision is made autonomously and knowledgeably.
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Related Practice
Textbook Question

Ethical and social issues have become a large part of the public discussion of genetics and genetic testing. Choose two of the propositions presented here and prepare a list of arguments for and against them.

The results of genetic testing for susceptibility to cancer, heart disease, and diabetes should be available to insurance companies and current or prospective employers to provide more information for decision-making.

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Textbook Question

Ethical and social issues have become a large part of the public discussion of genetics and genetic testing. Choose two of the propositions presented here and prepare a list of arguments for and against them.

Prenatal genetic testing and genetic testing of newborn infants should be available for hereditary conditions that can be treated or managed.

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Textbook Question

Ethical and social issues have become a large part of the public discussion of genetics and genetic testing. Choose two of the propositions presented here and prepare a list of arguments for and against them.

Prenatal genetic testing and genetic testing later in life should be available for hereditary conditions that cannot currently be treated or effectively managed.

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Textbook Question

In certain cases, genetic testing can identify mutant alleles that greatly increase a person's chance of developing a disease such as breast cancer or colon cancer. Between 50 and 70% of people with these particular mutations will develop cancer, but the rest will not. Imagine you are either a 30-year-old woman with a family history of breast cancer or a 30-year-old man with a family history of colon cancer (choose one). Each person can undergo genetic testing to identify a mutation that greatly increases susceptibility to the disease. Putting yourself in the place of the person you have chosen, provide answers to the following questions.

If you have a spouse or partner, are you obligated to tell that person the result of the genetic test? Why or why not?

440
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Textbook Question

In certain cases, genetic testing can identify mutant alleles that greatly increase a person's chance of developing a disease such as breast cancer or colon cancer. Between 50 and 70% of people with these particular mutations will develop cancer, but the rest will not. Imagine you are either a 30-year-old woman with a family history of breast cancer or a 30-year-old man with a family history of colon cancer (choose one). Each person can undergo genetic testing to identify a mutation that greatly increases susceptibility to the disease. Putting yourself in the place of the person you have chosen, provide answers to the following questions.

If you have children, are you obligated to tell the children the result of the genetic test? Why or why not?

518
views
Textbook Question

In certain cases, genetic testing can identify mutant alleles that greatly increase a person's chance of developing a disease such as breast cancer or colon cancer. Between 50 and 70% of people with these particular mutations will develop cancer, but the rest will not. Imagine you are either a 30-year-old woman with a family history of breast cancer or a 30-year-old man with a family history of colon cancer (choose one). Each person can undergo genetic testing to identify a mutation that greatly increases susceptibility to the disease. Putting yourself in the place of the person you have chosen, provide answers to the following questions.

If you were the spouse or partner of the person you have selected, would you encourage or would you discourage the person from having the genetic test? Why?

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