Skip to main content
Pearson+ LogoPearson+ Logo
Ch. 14 - Analysis of Gene Function via Forward Genetics and Reverse Genetics
Sanders - Genetic Analysis: An Integrated Approach 3rd Edition
Sanders3rd EditionGenetic Analysis: An Integrated ApproachISBN: 9780135564172Not the one you use?Change textbook
All textbooksSanders 3rd EditionCh. 14 - Analysis of Gene Function via Forward Genetics and Reverse GeneticsProblem C.9c
Chapter 14, Problem C.9c

Go to the website http://www.cancer.gov and select 'Cancer Types' on the top menu bar. Scroll down to 'Breast Cancer' and click. Select 'Cases & Prevention' from the options. Click 'More information' and select 'BRCA Mutations: Cancer Risk and Genetic Testing'. Use the information on this page to answer the following questions. With regard to the results of genetic testing for BRCA1 and BRCA2 mutations, what is meant by a 'positive result'?

Verified step by step guidance
1
Understand that BRCA1 and BRCA2 are genes where certain mutations can significantly increase the risk of developing breast and other cancers.
Recognize that genetic testing for BRCA mutations involves analyzing a person's DNA to identify specific changes or variants in these genes.
A 'positive result' in this context means that the genetic test has detected a mutation in either the BRCA1 or BRCA2 gene that is known to be associated with a higher risk of cancer.
This positive result indicates that the individual carries a hereditary mutation that may increase their likelihood of developing breast cancer or other related cancers compared to someone without the mutation.
It is important to note that a positive result does not guarantee cancer development but signifies an increased risk, which can guide medical management and preventive strategies.

Verified video answer for a similar problem:

This video solution was recommended by our tutors as helpful for the problem above.
Video duration:
2m
Was this helpful?

Key Concepts

Here are the essential concepts you must grasp in order to answer the question correctly.

BRCA1 and BRCA2 Genes

BRCA1 and BRCA2 are human genes that produce proteins responsible for repairing damaged DNA. Mutations in these genes can impair DNA repair, increasing the risk of developing breast and ovarian cancers. Understanding these genes is essential to grasp why their mutations are significant in cancer risk.
Recommended video:
Guided course
09:09
Mapping Genes

Genetic Testing and Mutation Detection

Genetic testing analyzes DNA to identify mutations in specific genes like BRCA1 and BRCA2. A 'positive result' means a harmful mutation was found, indicating a higher risk for certain cancers. This testing helps guide prevention and treatment decisions.
Recommended video:
Guided course
10:48
Mutations and Phenotypes

Implications of a Positive BRCA Test Result

A positive BRCA test result indicates the presence of a mutation that increases cancer risk but does not guarantee cancer development. It informs individuals about their elevated risk, enabling proactive measures such as increased screening, lifestyle changes, or preventive surgeries.
Recommended video:
Guided course
07:
Positional Cloning
Related Practice
Textbook Question

Genetic counseling has not been discussed in this chapter, but it is a service provided by trained professional counselors who also have detailed knowledge of medical genetics, as described in Application Chapter A. Genetic counselors provide details about gene mutations and have knowledge of most of the details of diseases associated with genetic abnormalities. With regard to genetic testing to identify one's personal risk of cancer, what are the three or four topics you think are most important to be able to discuss with a genetic counselor?

620
views
Textbook Question

Radiation is frequently used as part of the treatment of cancer. The radiation works by damaging DNA and components of the cell. How can radiation treatment control or cure cancer?

597
views
Textbook Question

Radiation is frequently used as part of the treatment of cancer. The radiation works by damaging DNA and components of the cell. Is there a risk of damage to noncancer cells?

686
views
Textbook Question

The inheritance of certain mutations of BRCA1 can make it much more likely that a woman will develop breast or ovarian cancer in her lifetime. Can you say with certainty that a woman inheriting a mutation of BRCA1 will definitely develop breast or ovarian cancer in her lifetime? Why or why not?

451
views
Textbook Question

Go to the website http://www.cancer.gov and select 'Cancer Types' on the top menu bar. Scroll down to 'Breast Cancer' and click. Select 'Cases & Prevention' from the options. Click 'More information' and select 'BRCA Mutations: Cancer Risk and Genetic Testing'. Use the information on this page to answer the following questions. What are the approximate percentage increases in risk of having breast cancer and of having ovarian cancer for women inheriting harmful mutations of BRCA1 and BRCA2 compared with the risks in the general population?

466
views
Textbook Question

Go to the website http://www.cancer.gov and select 'Cancer Types' on the top menu bar. Scroll down to 'Breast Cancer' and click. Select 'Cases & Prevention' from the options. Click 'More information' and select 'BRCA Mutations: Cancer Risk and Genetic Testing'. Use the information on this page to answer the following questions. What features of family history increase the likelihood that a woman will have a harmful mutation of BRCA1 or BRCA2?

428
views