Using the data in Table B, calculate the average number of kilobase (kb) pairs per centimorgan in the six multicellular eukaryotic organisms. How would this information influence strategies to clone genes known only by a mutant phenotype in these organisms?

Question

Using the data in Table B, calculate the average number of kilobase (kb) pairs per centimorgan in the six multicellular eukaryotic organisms. How would this information influence strategies to clone genes known only by a mutant phenotype in these organisms?

Table displaying binomial coefficients for events 0 to 12, highlighting the row for 6 events with total combinations of 64.

Accepted Answer

Welcome back, everybody. Here's our next question in Dr Sophal Melani gastro, a recessive mutation causes white eyes instead of the typical red eyes. The gene responsible for eye color is located on the X chromosome, which of the following statements about the influence of genome size in locating the gene is true. A larger genomes are easier to analyze b smaller genomes are time consuming. C larger genomes are more challenging and time consuming or D genome size will not affect the strategies that can be used. Well, this one is pretty nice and straightforward for us. We know that to locate a gene, you use various strategies of gene mapping such as recombination studies and sequencing of DNA, looking for the gene gene in the DNA sequence based on comparable genes in other species. And it's pretty logical that the larger the genome, the more base pairs you have to go through. The more possibilities for gene location, the more difficult it will be to find the gene. So we can pretty easily eliminate choice d that genome size will not affect the strategies that are used. And when we look at our other entry choices, we would say that choice c larger genomes are more challenging and time consuming A and B have this reversed. With a saying that larger genomes are easier and B that smaller genomes are time consuming. So they're not correct. And indeed, when we look at Drosophila, it has about 100 50 million base pairs, which is pretty large for an insect and would be difficult to go through the whole thing looking for a gene. But in the example, given our question, we know the gene is located on the X chromosome, which you could see by a pattern of inheritance. And that would obviously make your search a lot easier because you're narrowed down to just one X chromosome. So you'd have different strategies for that and you'd be having a much easier task than if you had to search all 150 million base pairs. But again, the influence of genome size on locating a gene choice, c larger genomes are more challenging and time consuming. See you in the next video.

Using the data in Table B, calculate the average number of kilobase (kb) pairs per centimorgan in the six multicellular eukaryotic organisms. How would this information influence strategies to clone genes known only by a mutant phenotype in these organisms?

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Key Concepts

Kilobase (kb) and Centimorgan (cM)

Gene Cloning

Mutant Phenotype