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Ch. 5 - Genetic Linkage and Mapping in Eukaryotes
Sanders - Genetic Analysis: An Integrated Approach 3rd Edition
Sanders3rd EditionGenetic Analysis: An Integrated ApproachISBN: 9780135564172Not the one you use?Change textbook
Chapter 5, Problem 25c

In rabbits, chocolate-colored fur (w⁺) is dominant to white fur (w), straight fur (c⁺) is dominant to curly fur (c), and long ear (s⁺) is dominant to short ear (s). The cross of a trihybrid rabbit with straight, chocolate-colored fur and long ears to a rabbit that has white, curly fur and short ears produces the following results:
Table displaying phenotypes and their corresponding numbers from a trihybrid rabbit cross experiment.
Determine the interference value for this cross.

Verified step by step guidance
1
Step 1: Understand the problem. The goal is to calculate the interference value for this cross. Interference measures the degree to which one crossover event in a region of a chromosome affects the likelihood of another crossover event occurring nearby. To calculate interference, we need to determine the coefficient of coincidence (C) and use the formula: Interference = 1 - C.
Step 2: Identify the parental and recombinant phenotypes. Parental phenotypes are the most frequent phenotypes in the offspring, while recombinant phenotypes are less frequent. From the data, the parental phenotypes are 'Chocolate, short, straight' (436) and 'White, long, curly' (450). The recombinant phenotypes are the remaining categories.
Step 3: Calculate the observed double crossover (DCO) frequency. Double crossover phenotypes are the least frequent phenotypes in the offspring. From the data, the DCO phenotypes are 'White, short, straight' (13) and 'Chocolate, long, curly' (13). Add these numbers to get the observed DCO frequency.
Step 4: Calculate the expected double crossover (DCO) frequency. To do this, first calculate the recombination frequencies for each pair of genes (e.g., fur color and fur texture, fur texture and ear length). Multiply these recombination frequencies together and then multiply by the total number of offspring (1400) to get the expected DCO frequency.
Step 5: Calculate the coefficient of coincidence (C) and interference. The coefficient of coincidence is calculated as C = (Observed DCO) / (Expected DCO). Finally, calculate the interference using the formula: Interference = 1 - C.

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Key Concepts

Here are the essential concepts you must grasp in order to answer the question correctly.

Dominance in Genetics

Dominance refers to the relationship between alleles, where one allele masks the expression of another. In this case, chocolate-colored fur (w⁺) is dominant over white fur (w), meaning that rabbits with at least one w⁺ allele will exhibit chocolate fur. Understanding dominance is crucial for predicting phenotypes in genetic crosses.
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Trihybrid Cross

A trihybrid cross involves three pairs of contrasting traits, allowing the study of inheritance patterns for multiple genes simultaneously. In this scenario, the traits for fur color, fur texture, and ear length are analyzed together. The results from such crosses can be used to determine the ratios of different phenotypes in the offspring.
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Genetic Interference

Genetic interference occurs when the occurrence of one crossover event in meiosis affects the likelihood of another crossover event happening nearby. This concept is important for understanding the distribution of traits in offspring. The interference value can be calculated using observed and expected frequencies of phenotypes, providing insights into the genetic linkage and recombination rates.
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Related Practice
Textbook Question

The boss in your laboratory has just heard of a proposal by another laboratory that genes for eye color and the length of body bristles may be linked in Drosophila. Your lab has numerous pure-breeding stocks of Drosophila that could be used to verify or refute genetic linkage. In Drosophila, red eyes (c⁺) are dominant to brown eyes (c) and long bristles (d⁺) are dominant to short bristles (d). Your lab boss asks you to design an experiment to test the genetic linkage of eye color and bristle-length genes, and to begin by crossing a pure-breeding line homozygous for red eyes and short bristles to a pure-breeding line that has brown eyes and long bristles.


How would the results of the cross differ if the genes are not linked?

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Textbook Question

In rabbits, chocolate-colored fur (w⁺) is dominant to white fur (w), straight fur (c⁺) is dominant to curly fur (c), and long ear (s⁺) is dominant to short ear (s). The cross of a trihybrid rabbit with straight, chocolate-colored fur and long ears to a rabbit that has white, curly fur and short ears produces the following results:

Determine the order of the genes on the chromosome, and identify the alleles that are present on each of the homologous chromosomes in the trihybrid rabbits.

447
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Textbook Question

In rabbits, chocolate-colored fur (w⁺) is dominant to white fur (w), straight fur (c⁺) is dominant to curly fur (c), and long ear (s⁺) is dominant to short ear (s). The cross of a trihybrid rabbit with straight, chocolate-colored fur and long ears to a rabbit that has white, curly fur and short ears produces the following results:

Calculate the recombination frequencies between each of the adjacent pairs of genes.

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Textbook Question

The following progeny are obtained from a test cross of a trihybrid wild-type plant to a plant with the recessive phenotypes compound leaves (c), intercalary leaflets (i), and green fruits (g). (Traits not listed are wild type.) The test-cross progeny are as follows:

Determine the order of the three genes, and construct a genetic map that identifies the correct order and the alleles carried on each chromosome in the trihybrid parental plant.

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Textbook Question

The following progeny are obtained from a test cross of a trihybrid wild-type plant to a plant with the recessive phenotypes compound leaves (c), intercalary leaflets (i), and green fruits (g). (Traits not listed are wild type.) The test-cross progeny are as follows:

Calculate the frequencies of recombination between the adjacent genes in the map.

447
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Textbook Question

The following progeny are obtained from a test cross of a trihybrid wild-type plant to a plant with the recessive phenotypes compound leaves (c), intercalary leaflets (i), and green fruits (g). (Traits not listed are wild type.) The test-cross progeny are as follows:

How many double-crossover progeny are expected among the test-cross progeny? Calculate the interference for this cross.

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