BackThere are other condensation reactions similar to the aldol and Claisen condensations:
c. The Knoevenagel condensation is the condensation of an aldehyde or a ketone that has no a-hydrogens and a compound such as diethyl malonate that has an a-carbon flanked by two electron-withdrawing groups. Draw the product obtained from the following Knoevenagel condensation:
The Knoevenagel condensation is a special case of the aldol condensation in which an active methylene compound reacts with an aldehyde or ketone, in the presence of a secondary amine as a basic catalyst, to produce a new C=C. Show the starting materials that made each of these by a Knoevenagel condensation.
(a)
Show how you would use an aldol, Claisen, or another type of condensation to make each compound.
(a)
Propose mechanisms for the reactions shown in Problems 22-63 part (b).
Show how you would use an aldol, Claisen, or another type of condensation to make each compound.
(f)
Propose a mechanism for the crossed Claisen condensation between ethyl acetate and ethyl benzoate.
Design a synthesis for each of the following compounds using the given starting material:
b.