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Ch. 21 - Genomic Analysis
Klug - Concepts of Genetics  12th Edition
Klug12th EditionConcepts of Genetics ISBN: 9780135564776Not the one you use?Change textbook
Chapter 21, Problem 22a

Homology can be defined as the presence of common structures because of shared ancestry. Homology can involve genes, proteins, or anatomical structures. As a result of 'descent with modification,' many homologous structures have adapted different purposes.
List three anatomical structures in vertebrates that are homologous but have different functions.

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Understand the concept of homology: Homologous structures are anatomical features that share a common evolutionary origin but may serve different functions in various organisms due to adaptation.
Identify examples of homologous structures in vertebrates: These structures should have a shared ancestry but have evolved to perform distinct functions.
Example 1: The forelimbs of mammals, such as the human arm, bat wing, and whale flipper, are homologous structures. They share the same skeletal framework but are adapted for different functions like grasping, flying, and swimming.
Example 2: The hindlimbs of vertebrates, such as the frog's jumping legs and the horse's running legs, are homologous structures adapted for different modes of locomotion.
Example 3: The vertebrate jawbones, such as the human mandible and the snake's jaw, are homologous structures that have evolved for different feeding strategies.

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Key Concepts

Here are the essential concepts you must grasp in order to answer the question correctly.

Homologous Structures

Homologous structures are anatomical features in different species that share a common ancestry, even if their functions have diverged. For example, the forelimbs of mammals, birds, and reptiles exhibit similar bone structures, indicating they evolved from a common ancestor, but they serve different purposes such as grasping, flying, or swimming.
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Descent with Modification

Descent with modification is a key principle of evolutionary biology, suggesting that species evolve over time through changes in their traits. This process leads to variations in homologous structures as they adapt to different environments and functions, resulting in diverse forms while retaining underlying similarities.
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Adaptive Radiation

Adaptive radiation is an evolutionary process where organisms diversify rapidly into a variety of forms to adapt to different environments. This phenomenon often results in homologous structures that have evolved to fulfill distinct roles, such as the varying limb structures in vertebrates that have adapted for different modes of life, like running, swimming, or flying.
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Related Practice
Textbook Question

An interactive Web site for the Human Proteome Map (HPM) is available at http://www.humanproteomemap.org. Visit this site, and then answer the question.

How many fetal tissues were analyzed?

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Textbook Question

An interactive Web site for the Human Proteome Map (HPM) is available at http://www.humanproteomemap.org. Visit this site, and then answer the question.

Use the 'Query' tab and select the 'Gene family' dropdown menu to do a search on the distribution of proteins encoded by a pathway of interest to you. Search in fetal tissues, adult tissues, or both.

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Textbook Question

Researchers have compared candidate loci in humans and rats in search of loci in the human genome that are likely to contribute to the constellation of factors leading to hypertension [Stoll, M., et al. (2000). Genome Res. 10:473–482]. Through this research, they identified 26 chromosomal regions that they consider likely to contain hypertension genes. How can comparative genomics aid in the identification of genes responsible for such a complex human disease? The researchers state that comparisons of rat and human candidate loci to those in the mouse may help validate their studies. Why might this be so?

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Textbook Question

Homology can be defined as the presence of common structures because of shared ancestry. Homology can involve genes, proteins, or anatomical structures. As a result of 'descent with modification,' many homologous structures have adapted different purposes.

Is it likely that homologous proteins from different species have the same or similar functions? Explain.

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Textbook Question

Homology can be defined as the presence of common structures because of shared ancestry. Homology can involve genes, proteins, or anatomical structures. As a result of 'descent with modification,' many homologous structures have adapted different purposes.

Under what circumstances might one expect proteins of similar function to not share homology? Would you expect such proteins to be homologous at the level of DNA sequences?

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Textbook Question

Comparisons between human and chimpanzee genomes indicate that a gene that may function as a wild-type or normal gene in one primate may function as a disease-causing gene in another [The Chimpanzee Sequencing and Analysis Consortium (2005). Nature 437:69–87]. For instance, the PPARG locus (regulator of adipocyte differentiation) is a wild-type allele in chimps but is clearly associated with Type 2 diabetes in humans. What factors might cause this apparent contradiction? Would you consider such apparent contradictions to be rare or common? What impact might such findings have on the use of comparative genomics to identify and design therapies for disease-causing genes in humans?

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