Textbook Question
What are DNA microarrays? How are they used?
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Ch. 21 - Genomic Analysis
Klug12th EditionConcepts of Genetics ISBN: 9780135564776
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Table of contents
- Ch. 1 - Introduction to Genetics17
- Ch. 2 - Mitosis and Meiosis36
- Ch. 3 - Mendelian Genetics51
- Ch. 4 - Extensions of Mendelian Genetics74
- Ch. 5 - Chromosome Mapping in Eukaryotes51
- Ch. 6 - Genetic Analysis and Mapping in Bacteria and Bacteriophages46
- Ch. 7 - Sex Determination and Sex Chromosomes33
- Ch. 8 - Chromosome Mutations: Variation in Number and Arrangement40
- Ch. 9 - Extranuclear Inheritance31
- Ch. 10 - DNA Structure and Analysis43
- Ch. 11 - DNA Replication and Recombination44
- Ch. 12 - DNA Organization in Chromosomes30
- Ch. 13 - The Genetic Code and Transcription54
- Ch. 14 - Translation and Proteins47
- Ch. 15 - Gene Mutation, DNA Repair, and Transposition41
- Ch. 16 - Regulation of Gene Expression in Bacteria29
- Ch. 17 - Transcriptional Regulation in Eukaryotes41
- Ch. 18 - Post-transcriptional Regulation in Eukaryotes33
- Ch. 19 - Epigenetics33
- Ch. 20 - Recombinant DNA Technology44
- Ch. 21 - Genomic Analysis36
- Ch. 22 - Applications of Genetic Engineering and Biotechnology36
- Ch. 23 - Developmental Genetics37
- Ch. 24 - Cancer Genetics34
- Ch. 25 - Quantitative Genetics and Multifactorial Traits54
- Ch. 26 - Population and Evolutionary Genetics45
Chapter 21, Problem 20b
An interactive Web site for the Human Proteome Map (HPM) is available at http://www.humanproteomemap.org. Visit this site, and then answer the question.
How many fetal tissues were analyzed?
Verified step by step guidance1
Since the question asks about the number of fetal tissues analyzed in the Human Proteome Map (HPM), the first step is to understand what the Human Proteome Map is: it is a resource that catalogs protein expression across various human tissues, including fetal and adult tissues.
Next, visit the website http://www.humanproteomemap.org as instructed, and navigate to the section or dataset that lists the tissues analyzed. This might be under categories like 'Tissue Atlas' or 'Data Overview'.
Look specifically for the fetal tissue category or filter the data to show only fetal tissues. The website should provide a list or a count of fetal tissues included in the analysis.
Count the number of distinct fetal tissues listed or reported in the dataset. This number represents how many fetal tissues were analyzed in the Human Proteome Map.
If the website provides downloadable data or supplementary information, you can verify the count by reviewing the metadata or documentation files that accompany the proteome data.
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Key Concepts
Here are the essential concepts you must grasp in order to answer the question correctly.
Human Proteome Map (HPM)
The Human Proteome Map is an online resource that catalogs protein expression across various human tissues and organs. It provides data on protein presence and abundance, helping researchers understand tissue-specific protein profiles, including fetal and adult tissues.
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Proteomics
Fetal Tissue Analysis in Proteomics
Fetal tissue analysis involves studying protein expression in tissues from developing embryos or fetuses. This helps identify developmental stage-specific proteins and understand growth processes, which differ from adult tissue protein profiles.
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Navigating and Interpreting Online Biological Databases
Effectively using biological databases like the HPM requires skills in navigating web interfaces, locating relevant datasets, and interpreting summary statistics or metadata, such as the number of tissues analyzed, to answer specific research questions.
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Related Practice
Textbook Question
Annotation of the human genome sequence reveals a discrepancy between the number of protein-coding genes and the number of predicted proteins actually expressed by the genome. Proteomic analysis indicates that human cells are capable of synthesizing more than 100,000 different proteins and perhaps three times this number. What is the discrepancy, and how can it be reconciled?
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Textbook Question
An interactive Web site for the Human Proteome Map (HPM) is available at http://www.humanproteomemap.org. Visit this site, and then answer the question.
How many proteins were identified in this project?
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Textbook Question
An interactive Web site for the Human Proteome Map (HPM) is available at http://www.humanproteomemap.org. Visit this site, and then answer the question.
Use the 'Query' tab and select the 'Gene family' dropdown menu to do a search on the distribution of proteins encoded by a pathway of interest to you. Search in fetal tissues, adult tissues, or both.
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Textbook Question
Researchers have compared candidate loci in humans and rats in search of loci in the human genome that are likely to contribute to the constellation of factors leading to hypertension [Stoll, M., et al. (2000). Genome Res. 10:473–482]. Through this research, they identified 26 chromosomal regions that they consider likely to contain hypertension genes. How can comparative genomics aid in the identification of genes responsible for such a complex human disease? The researchers state that comparisons of rat and human candidate loci to those in the mouse may help validate their studies. Why might this be so?
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Textbook Question
Homology can be defined as the presence of common structures because of shared ancestry. Homology can involve genes, proteins, or anatomical structures. As a result of 'descent with modification,' many homologous structures have adapted different purposes.
List three anatomical structures in vertebrates that are homologous but have different functions.
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