Explain the features of the Initiator (Inr) elements, BREs, DPEs, and MTEs of focused promoters.

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Hi everyone welcome back. Here's our next problem blank. Are the D. N. A sequences that are located downstream of the transcription start site and are necessary for the binding of transcription factors. So we have multiple and you carry out multiple DNA sequences involved in the regulation of transcription of a specific gene. Um many of which are our most of which are upstream of the transcription start site but we also have some that are downstream. And so when we are looking through our answer choices we have luckily a nice kind of pointer to our correct answer here. In that we look for answer choices. We see choice C is called downstream promoter elements. Now we do have an answer choice that says choice D. None of these but we don't have one for all of these. So pretty clear clue that our answer we want to pick is downstream promoter elements. Since we're looking for a D. N. A sequence that's a downstream of the start site and these are DNA sequences downstream where transcription factors bind to regulate the expression or the transcription of that particular gene. When we look through other answer choices, obviously we can eliminate choice Dean none of these since we have that correct answer. And see um choice a basil regulatory elements and choice be multiple transcription enhancers. Both our D. N. A sequences that transcription factors bind to and then affect how the gene is the level to which the gene is transcribed there near the promoter but they are both upstream of that transcription start site which is why they're not the correct answers. So we go ahead, eliminate them. Basil regulatory elements are sometimes known as general transcription elements and they're necessary for the initiation of transcription. Transcription factors, bind them and then interact with the promoter to begin transcription. And then multiple transcription enhancers, as their name indicates, are enhancers, meaning they help to up regulate the transcription of the gene to increase the level which is transcribed. They're located upstream of course and they are controlled by multiple transcription factors that in specific combination begin to turn up transcription of the gene. But again, both of those A and B. Are located upstream and therefore not our answer. So which the D. N. A sequences located downstream of the transcription start site? Our choice C downstream promoter elements. See you in the next video.

Explain the features of the Initiator (Inr) elements, BREs, DPEs, and MTEs of focused promoters.

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Key Concepts

Initiator (Inr) Element

TFIIB Recognition Elements (BREs)

Downstream Promoter Elements (DPEs) and Motif Ten Elements (MTEs)